05207nam 2200625Ia 450 991046377510332120200520144314.01-61705-140-3(CKB)2670000000402555(EBL)1336608(OCoLC)855505060(SSID)ssj0000949818(PQKBManifestationID)12412553(PQKBTitleCode)TC0000949818(PQKBWorkID)11003400(PQKB)11703070(MiAaPQ)EBC1336608(Au-PeEL)EBL1336608(CaPaEBR)ebr10742089(CaONFJC)MIL539920(OCoLC)857064804(EXLCZ)99267000000040255520130520d2014 uy 0engur|n|---|||||txtccrCancer biology review[electronic resource] a case-based approach /editor, Walter M. StadlerNew York Demos Medical Publishing, LLC20141 online resource (208 p.)Description based upon print version of record.1-936287-85-4 Includes bibliographical references and index.Cover; Title; Copyright; Contents; Contributors; Preface; 1. DNA Synthesis and Repair; A. Fundamentals of DNA Synthesis; Manish Sharma and Blase Polite; Overview; Clinical Translation: Mechanism of Action for Nucleotide Analog Agents and Antifolates; Clinical Translation: Mechanism of Action for Topoisomerase-Interacting Agents; Key Concepts; References; B. Fundamentals of DNA Damage and Repair; Philip Connell and Rita Nanda; Overview; Clinical Translation: Mechanism of Action for Radiotherapy; Clinical Translation: Mechanism of Action for Platinum AnalogsClinical Translation: BRCA1/2: Cancer Predisposition and Interaction With PARP InhibitorsClinical Translation: Hereditary Nonpolyposis Colorectal Cancer Predisposition Syndromes; Key Concepts; References; C. DNA Mutations and Alterations: Applications to Cancer Therapy; Amy L. Kaufman and Peter H. O'Donnell; Overview; Clinical Translation: Irinotecan; Clinical Translation: 6-Mercaptopurine; Key Concepts; References; 2. RNA Transcription and Translation; A. Fundamentals of RNA Transcription and Translation; Overview; Clinical Translation: Transcriptional Profiling in Cancer; Key ConceptsReferencesBibliography; B. microRNAs; Overview; Clinical Translation: microRNAs Diagnostics; Key Concepts; References; Bibliography; 3. Chromosomal Dynamics and Stability; A. Fundamentals of Chromosomal Organization and Epigenetic Modification; Christopher J. Mariani, Erika L. Moen, Kelly R. Ostler, and Lucy A. Godley; Overview; Clinical Translation: Mechanism of Action for Histone Deacetylase Inhibitors; Clinical Translation: Mechanism of Action of Hypomethylating Agents; Key Concepts; References; B. Fundamentals of Chromosome Structure and SegregationChristopher J. Mariani, Trisha Macrae, Michael Daunov, and Lucy A. GodleyOverview; Clinical Translation: Cancer Associated Chromosomal Translocations as Diagnostic Markers; Clinical Translation: Mechanism of Tubule Inhibitors; Key Concepts; References; 4. Cell Surface Receptors and Signal Transduction; A. Fundamentals of Growth Factor Receptor Tyrosine Kinase Signaling; Overview; Clinical Translation: Mechanism of Action of EGFR/HER2 and MET Inhibitors; Key Concepts; References; B. Fundamentals of Signal Transduction; OverviewClinical Translation: Clinical Implications for RAF and RAS MutationsClinical Translation: Mechanism of Action for PI3K and AKT Pathway Inhibitors; Clinical Translation: Mechanism of Action of IL6/JAK/STAT Inhibitors; Key Concepts; References; 5. Nuclear Hormone Receptors; A. Overview of Nuclear Hormone Receptors in Malignancy; Russell Z. Szmulewitz; References; B. Androgen Receptor and Estrogen Receptor; Russell Z. Szmulewitz and James E. Ward; Overview; Clinical Translation: Mechanism of Estrogen Receptor (ER) Antagonism in Breast CancerClinical Translation: Modulation of the AR Axis in Prostate CancerUtilizing the teaching value of real-world case discussions, Cancer Biology Review presents the principles of cancer biology in a clear and memorable manner, allowing the clinician to relate the cases shown in the book to those seen in practice. Focusing on ten topics in cancer biology for which there have been major changes in fundamental understanding, the authors provide a concise overview of the principles of each topic, followed by presentation of clinical cases illuminating the topic and detailed discussions. Summaries and key teaching points are highlighted at the end of each chapter toCancerGenetic aspectsCase studiesCancerResearchElectronic books.CancerGenetic aspectsCancerResearch.362.19699/40072Stadler Walter Michael869572MiAaPQMiAaPQMiAaPQBOOK9910463775103321Cancer biology review1941403UNINA