04676nam 2200685 a 450 991046334920332120200520144314.03-11-026037-910.1515/9783110260373(CKB)2670000000328236(EBL)893175(OCoLC)826482554(SSID)ssj0000819052(PQKBManifestationID)11463154(PQKBTitleCode)TC0000819052(PQKBWorkID)10844224(PQKB)10951172(MiAaPQ)EBC893175(DE-B1597)171778(OCoLC)880404765(OCoLC)948656048(DE-B1597)9783110260373(Au-PeEL)EBL893175(CaPaEBR)ebr10649214(EXLCZ)99267000000032823620120801d2012 uy 0engur|n|---|||||txtccrKallikrein-related peptidases[electronic resource] Volume 1Characterization, regulation, and interactions within the protease web /Viktor Magdolen ... [et al.], editorsBerlin Walter de Gruyterc20121 online resource (428 p.)Kallikrein-related peptidases ;Volume 1Description based upon print version of record.3-11-048151-0 3-11-026036-0 Includes bibliographical references and index.Genomic structure of the KLK locus -- Single nucleotide polymorphisms in the human KLK locus and their implication in various diseases -- Evolution of Kallikrein-related peptidases -- Structural aspects of Kallikrein-related peptidases -- Molecular recognition properties of Kallikrein-related peptidases on synthetic and endogenous substrates -- Natural, engineered, and synthetic inhibitors of Kallikrein-related peptidases -- Kallikrein-related peptidases as pharmaceutical targets -- Expression of Kallikrein-related peptidases under (patho) physiological conditions -- Kallikrein-related peptidases within the proteolytic web -- Kallikrein-Kinin cascade: bioregulation by human tissue kallikrein 1 (HK1, KLK 1) -- Role of KLK4 in dental enamel formation.Kallikrein-related peptidases and semen -- Kallikrein-related peptidases and inhibitors of the skin -- Physiological and pathophysiological roles of Kallikrein-related peptidases in the central nervous system -- Kallikrein-related peptidases (KLKS), proteinase-mediated signaling and proteinase-activated receptors (PARS) -- Pathophysiology of Kallikrein-related peptidases in lung cancer -- Clinical relevance of Kallikrein-related peptidases in gastric and colorectal cancer -- Pathophysiology of Kallikrein-related peptidases in head and neck cancer -- PSA (prostate-specific antigen) and other Kallikrein-related peptidases in prostate cancer -- Cellular model systems to study the tumor biological role of Kallikrein-related peptidases in ovarian and prostate cancer -- Clinical relevance of Kallikrein-related peptidases in breast cancer -- Clinical relevance of Kallikrein-related peptidases in ovarian cancer -- MicroRNAs : a new control mechanism for Kallikrein-related peptidases in kidney and other cancers -- Genomic instability of the KLK-locus in cancer -- Kallikrein-related peptidases as biomarkers in personalized cancer medicine.This handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function.KallikreinGeneticsKallikreinMetabolismTumorsGeneticsProteolytic enzymesMetabolismElectronic books.KallikreinGenetics.KallikreinMetabolism.TumorsGenetics.Proteolytic enzymesMetabolism.616.99/4042Magdolen Viktor1029981MiAaPQMiAaPQMiAaPQBOOK9910463349203321Kallikrein-related peptidases2491565UNINA