04383nam 2200721 450 991046278610332120200520144314.00-231-53127-310.7312/kahn16298(CKB)2670000000314982(EBL)1028090(OCoLC)818814876(SSID)ssj0000785124(PQKBManifestationID)11501075(PQKBTitleCode)TC0000785124(PQKBWorkID)10804126(PQKB)10175167(StDuBDS)EDZ0000101029(MiAaPQ)EBC1028090(DE-B1597)458982(OCoLC)979626630(DE-B1597)9780231531276(Au-PeEL)EBL1028090(CaPaEBR)ebr10975960(CaONFJC)MIL666243(EXLCZ)99267000000031498220141121h20132013 uy 0engur|n|---|||||txtccrRace in a bottle the story of BiDil and racialized medicine in a post-genomic age /Jonathan Kahn ; cover design by David DrummondNew York ;Chichester, England :Columbia University Press,2013.©20131 online resource (329 p.)Includes index.1-322-34961-4 0-231-16298-7 Includes bibliographical references and index.Frontmatter -- Contents -- Acknowledgments -- INTRODUCTION: Race and Medicine: Framing [Is] the Problem -- 1. Organizing race -- 2. The Birth of Bidil -- 3. Statistical Mischief and Racial Frames for Drug Development and Marketing -- 4. Capitalizing [on] Race in Drug Development -- 5. Race-ing Patents/ Patenting Race -- 6. Not Fade Away -- 7. From Disparity to Difference -- Conclusions and Recommendations -- Notes -- IndexAt a ceremony announcing the completion of the first draft of the human genome in 2000, President Bill Clinton declared, "I believe one of the great truths to emerge from this triumphant expedition inside the human genome is that in genetic terms, all human beings, regardless of race, are more than 99.9 percent the same." Yet despite this declaration of unity, biomedical research has focused increasingly on mapping that.1 percent of difference, particularly as it relates to race.This trend is exemplified by the drug BiDil. Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was originally touted as a pathbreaking therapy to treat heart failure in black patients and help underserved populations. Upon closer examination, however, Jonathan Kahn reveals a far more complex story. At the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked. Using BiDil as a central case study, Kahn broadly examines the legal and commercial imperatives driving the expanding role of race in biomedicine, even as scientific advances in genomics could render the issue irrelevant. He surveys the distinct politics informing the use of race in medicine and the very real health disparities caused by racism and social injustice that are now being cast as a mere function of genetic difference. Calling for a more reasoned approach to using race in biomedical research and practice, Kahn asks readers to recognize that, just as genetics is a complex field requiring sensitivity and expertise, so too is race, particularly in the field of biomedicine.HydralazineDevelopmentHistoryHealth and raceAfrican AmericansMedical carePharmacogeneticsSocial aspectsPharmaceutical industryPolitical aspectsUnited StatesElectronic books.HydralazineDevelopmentHistory.Health and race.African AmericansMedical care.PharmacogeneticsSocial aspects.Pharmaceutical industryPolitical aspects616.1/2906108996073Kahn Jonathan1045382Drummond DavidMiAaPQMiAaPQMiAaPQBOOK9910462786103321Race in a bottle2471626UNINA03056nam 2200649Ia 450 991082275260332120240514073828.01-280-59088-297866136207121-118-19774-71-118-19771-21-118-19772-0(CKB)2670000000148395(EBL)822079(OCoLC)777374877(SSID)ssj0000652339(PQKBManifestationID)11413581(PQKBTitleCode)TC0000652339(PQKBWorkID)10636951(PQKB)11465170(MiAaPQ)EBC822079(Au-PeEL)EBL822079(CaPaEBR)ebr10534025(CaONFJC)MIL362071(EXLCZ)99267000000014839520120309d2012 uy 0engur|n|---|||||txtccrAdvances in chemical physicsVolume 150 /edited by Sturat A. Rice, Aaron R. Dinner1st ed.Hoboken Wiley20121 online resource (374 p.)Advances in Chemical PhysicsDescription based upon print version of record.1-118-16784-8 Includes bibliographical references and indexes.Advances in Chemical Physics; CONTENTS; Multidimensional Incoherent Time-Resolved Spectroscopy and Complex Kinetics; Complex Multiconfigurational Self-Consistent Field-Based Methods to Investigate Electron-Atom/Molecule Scattering Resonances; Determination of Molecular Orientational Correlations in Disordered Systems from Diffraction Data; Recent Advances in Studying Mechanical Properties of DNA; Viscoelastic Subdiffusion: Generalized Langevin Equation Approach; Efficient and Unbiased Sampling of Biomolecular Systems in the Canonical Ensemble: A Review of Self-Guided Langevin DynamicsAuthor IndexSubject Index The Advances in Chemical Physics series-the cutting edge of research in chemical physics The Advances in Chemical Physics series provides the chemical physics and physical chemistry fields with a forum for critical, authoritative evaluations of advances in every area of the discipline. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series presents contributions from internationally renowned chemists and serves as the perfect supplement to any advanced graduate class devoted to the sAdvances in Chemical PhysicsChemistry, Physical and theoreticalChemistryChemistry, Physical and theoretical.Chemistry.541.3Rice Stuart Arthur1932-1686740Dinner Aaron R1622289MiAaPQMiAaPQMiAaPQBOOK9910822752603321Advances in chemical physics4059743UNINA