03621nam 2200769Ia 450 991046208010332120200520144314.01-283-63640-90-309-22419-5(CKB)2670000000275073(EBL)3379026(SSID)ssj0000665822(PQKBManifestationID)11422014(PQKBTitleCode)TC0000665822(PQKBWorkID)10646743(PQKB)10190436(MiAaPQ)EBC3379026(Au-PeEL)EBL3379026(CaPaEBR)ebr10606367(CaONFJC)MIL394886(OCoLC)923288397(EXLCZ)99267000000027507320120911d2012 uy 0engurcn|||||||||txtccrEvolution of translational omics[electronic resource] lessons learned and the path forward /Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials; Board on Health Care Services; Board on Health Sciences Policy ; Christine M. Micheel, Sharyl J. Nass, and Gilbert S. Omenn, editors ; Institutes of Medicine of the National AcademiesWashington, D.C. National Academies Pressc20121 online resource (338 p.)Description based upon print version of record.0-309-22418-7 Includes bibliographical references.""Front Matter""; ""Reviewers""; ""Acknowledgments""; ""Contents""; ""Boxes, Figures, and Tables""; ""Summary""; ""1 Introduction""; ""2 Omics-Based Clinical Discovery: Science, Technology, and Applications""; ""3 Best Practices for Omics-Based Test Validation Prior to Use for Patient Management Decisions in a Clinical Trial Setting""; ""4 Evaluation of Omics-Based Tests for Clinical Utility and Use""; ""5 Responsible Parties""; ""6 Lessons from the Case Studies""; ""Appendix A: Case Studies""""Appendix B: Gene Expression Based Tests Developed at Duke University and Used in Clinical Trials""""Appendix C: Introduction to Biomarkers""; ""Appendix D: Reporting Guidelines""; ""Appendix E: Committee Member and Staff Biographies""; ""Appendix F: Information Gathering Sessionsand Speakers""; ""Acronyms and Abbreviations""; ""Glossary""GenomicsTechnologyGenomicsData processingGenetic translationTechnologyBiomoleculesAnalysisBiomoleculesData processingBioinformaticsTechnologyBiotechnologyData miningAnalysisElectronic books.GenomicsTechnology.GenomicsData processing.Genetic translationTechnology.BiomoleculesAnalysis.BiomoleculesData processing.BioinformaticsTechnology.Biotechnology.Data miningAnalysis.572.33Micheel Christine870814Nass Sharyl J857626Omenn Gilbert S935718Institute of Medicine (U.S.).Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials.Institute of Medicine (U.S.).Board on Health Sciences Policy.National Academies Press (U.S.)MiAaPQMiAaPQMiAaPQBOOK9910462080103321Evolution of translational omics2140448UNINA