03096nam 2200637 a 450 991046161900332120200520144314.01-283-14344-597866131434401-84816-593-5(CKB)2670000000095737(EBL)731089(OCoLC)738433271(SSID)ssj0000522091(PQKBManifestationID)12205256(PQKBTitleCode)TC0000522091(PQKBWorkID)10522821(PQKB)10196654(MiAaPQ)EBC731089(WSP)0000P729(Au-PeEL)EBL731089(CaPaEBR)ebr10480223(CaONFJC)MIL314344(EXLCZ)99267000000009573720110714d2011 uy 0engur|n|---|||||txtccrDNA deamination and the immune system[electronic resource] AID in health and disease /editors, Sebastian Fugmann, Marilyn Diaz, Nina PapavasiliouLondon Imperial College Press20111 online resource (232 p.)Molecular medicine and medicinal chemistry ;v. 3Description based upon print version of record.1-84816-592-7 Includes bibliographical references and index.Preface; Contents; List of Tables; List of Figures; Chapter 1 Introduction; Chapter 2 Switch Regions, ChromatinAccessibility and AID Targeting; Chapter 3 Cis-Regulatory Elements that Target AID to Immunoglobulin Loci; Chapter 4 Partners in Diversity: The Search for AID Co-Factors; Chapter 5 Resolution of AID Lesions in Class Switch Recombination; Chapter 6 Error-Prone and Error-Free Resolution of AID Lesions in SHM; Chapter 7 Regulatory Mechanisms of AID Function; Chapter 8 AID in Immunodeficiency and Cancer; Chapter 9 AID in Aging and in Autoimmune Disease; IndexThis book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted Molecular medicine and medicinal chemistry ;v. 3.DNAImmune systemElectronic books.DNA.Immune system.571.967Fugmann Sebastian911294Diaz Marilyn911295Papavasiliou Nina911296MiAaPQMiAaPQMiAaPQBOOK9910461619003321DNA deamination and the immune system2040829UNINA