02470nam 2200577 a 450 991046161660332120200520144314.01-84973-301-5(CKB)2670000000096425(EBL)1185803(OCoLC)746035479(SSID)ssj0000578452(PQKBManifestationID)12187324(PQKBTitleCode)TC0000578452(PQKBWorkID)10578627(PQKB)11177410(MiAaPQ)EBC1185803(PPN)198466943(Au-PeEL)EBL1185803(CaPaEBR)ebr10627712(CaONFJC)MIL871756(EXLCZ)99267000000009642520121212d2011 uy 0engur|n|---|||||txtccrNeurodegeneration[electronic resource] metallostasis and proteostasis /edited by Danilo Milardi and Enrico RizzarelliCambridge RSC Pub.20111 online resource (285 p.)RSC drug discovery series,2041-3203 ;no. 7Description based upon print version of record.1-84973-050-4 Includes bibliographical references and index.i-iv; v-viii; xi-xiv; 1-17.PDF.pdf; 18-45; 46-68; 69-82; 83-111; 112-140; 141-151; 152-173; 174-211; 212-225; 226-248; 249-258; 259-270Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed ""amyloid"") in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. They have, consequently, been seen as a suitabRSC drug discovery series ;7.Nervous systemDegenerationElectronic books.Nervous systemDegeneration.616.8047Milardi Danilo931446Rizzarelli Enrico931447MiAaPQMiAaPQMiAaPQBOOK9910461616603321Neurodegeneration2095354UNINA