01597nam 2200409 450 00000100420050718115000.0--------d1935----km-y0itay0103----baitaITGerardo Raffaele ZitarosaOnorato FavaTrapaniCasa editrice "Radio"19357 p.25 cmScrittori religiosi contemporaneiQuaderni di "Parva lucerna"Sulla quarta di cop. pubblicità editorialeAll'interno due pagine diella rivista "La forgia. Pubblicazione varia di formazione spirituale letteraria ed artistica", Anno II, N. 11-12 (Nov.-Dic. 1934 - XII), Napoli. Dir. Mariano Luisi: con un articolo su Gerardo Raffaele ZitarosaEstratto dal fascicolo gennaio-febbraio 1935 (XIII)Zitarosa Gerardo RaffaeleFava,Onorato202517ITUniversità della Basilicata - B.I.A.RICAunimarc000001004Gerardo Raffaele Zitarosa70964UNIBASMONLETMONOGRLETTEREGINO0119990702BAS01123920000913BAS01142420000920BAS01182820001010BAS01163120050601BAS011752batch0120050718BAS01104720050718BAS01110620050718BAS01113620050718BAS011150BAS01BAS01BOOKBASA1Polo Storico-UmanisticoFDEPFondo De PilatoFD/17591759D17592003102852Rari04637nam 2200565 450 991046114340332120200520144314.00-12-802592-1(CKB)3710000000462443(EBL)2146996(MiAaPQ)EBC2146996(PPN)198666071(Au-PeEL)EBL2146996(CaPaEBR)ebr11090798(CaONFJC)MIL822677(OCoLC)918841190(EXLCZ)99371000000046244320150901d2015 uy| 0engur|n|---|||||rdacontentrdamediardacarrierBone morphogenic protein /series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, CaliforniaFirst edition.Waltham, MA :Elsevier,2015.1 online resource (367 p.)Vitamins and Hormones,0083-6729 ;volume 99Description based upon print version of record.0-12-802442-9 Includes bibliographical references and index.Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; ReferencesChapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc...Vitamins and hormones ;v. 99.Bone morphogenetic proteinsElectronic books.Bone morphogenetic proteins.612.75Litwack GeraldMiAaPQMiAaPQMiAaPQBOOK9910461143403321Bone morphogenic protein2241570UNINA