04562nam 2200649 450 991046024960332120200520144314.01-908818-68-91-907568-47-6(CKB)3710000000316671(EBL)1888544(SSID)ssj0001464907(PQKBManifestationID)12644139(PQKBTitleCode)TC0001464907(PQKBWorkID)11459331(PQKB)10878139(MiAaPQ)EBC1888544(Au-PeEL)EBL1888544(CaPaEBR)ebr10996817(CaONFJC)MIL785092(OCoLC)898422306(EXLCZ)99371000000031667120150106h20142014 uy 0engur|n|---|||||txtccrOral delivery of insulin /Thundiparambil Azeez Sonia, Chandra P. SharmaCambridge, England :Woodhead Publishing,2014.©20141 online resource (361 p.)Woodhead Publishing Series in Biomedicine ;Number 41Description based upon print version of record.0-08-101625-5 Includes bibliographical references and index.Cover; Oral Delivery of Insulin; Copyright; Contents; List of figures and tables; About the authors; 1 Diabetes mellitus - an overview; 1.1 Diabetes mellitus - an introduction; 1.2 Glucose homeostasis; 1.3 Types of diabetes; 1.4 Symptoms of diabetes; 1.5 Complications of diabetes; 1.6 Diagnosis of diabetes mellitus; 1.7 Therapy for diabetes; 1.8 Noninsulin treatment options of type 1 diabetes; 1.9 Treatment options of type 2 diabetes; 1.10 Conclusion; 1.11 References; 2 Routes of administration of insulin; 2.1 Current approach for the delivery of insulin2.2 Routes of administration of insulin2.3 Conclusion; 2.4 References; 3 Oral insulin delivery - challenges and strategies; 3.1 Oral delivery of insulin; 3.2 Barriers to oral delivery of insulin; 3.3 Strategies and alternatives to improve oral insulin delivery; 3.4 Conclusion; 3.5 References; 4 Experimental techniques involved in the development of oral insulin carriers; 4.1 Introduction; 4.2 Polymeric nanoparticles; 4.3 Physicochemical characterization of nanoparticles; 4.4 Biological evaluation; 4.5 In vitro method for assessing drug permeability; 4.6 In vivo study of oral insulin4.7 Biodistribution studies4.8 Conclusion; 4.9 References; 5 Lipids and inorganic nanoparticles in oral insulin delivery; 5.1 Lipid-based systems for oral delivery of insulin; 5.2 Liposomes; 5.3 Solid lipid nanoparticles; 5.4 Nanostructured lipid carriers; 5.5 Niosomes; 5.6 Archaeosomes; 5.7 Cubic nanoparticles (cubosomes); 5.8 Aquasomes; 5.9 Inorganic nanoparticles as carriers for oral insulin delivery; 5.10 Conclusion; 5.11 References; 6 Polymers in oral insulin delivery; 6.1 Introduction; 6.2 Characteristics of an ideal oral insulin carrier; 6.3 Polymers in oral insulin delivery6.4 Natural polymers6.5 Synthetic polymers; 6.6 Conclusion; 6.7 References; 7 Summary and future perspectives for oral insulin delivery; 7.1 Introduction; 7.2 Technologies developed for clinical applications of oral insulin delivery; 7.3 Conclusions and future perspectives; 7.4 References; IndexDiabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications andWoodhead Publishing series in biomedicine ;Number 41.InsulinTherapeutic useAdministrationDiabetesOral therapyElectronic books.InsulinTherapeutic useAdministration.DiabetesOral therapy.616.462061Sonia Thundiparambil Azeez965418Sharma Chandra P.MiAaPQMiAaPQMiAaPQBOOK9910460249603321Oral delivery of insulin2190367UNINA