05284nam 2200637 450 991045979730332120200520144314.00-12-416583-40-12-416579-6(CKB)3710000000312775(EBL)1887710(SSID)ssj0001454879(PQKBManifestationID)11820771(PQKBTitleCode)TC0001454879(PQKBWorkID)11499339(PQKB)10001221(MiAaPQ)EBC1887710(Au-PeEL)EBL1887710(CaPaEBR)ebr10999900(CaONFJC)MIL485029(OCoLC)898070405(EXLCZ)99371000000031277520150109h20152015 uy 0engur|n|---|||||txtccrChannels, carriers, and pumps an introduction to membrane transport /Wilfred D. Stein, Thomas LitmanSecond edition.London, England :Academic Press,2015.©20151 online resource (423 p.)Includes index.Front Cover; Channels, Carriers, and Pumps; Copyright Page; Dedications; Contents; Preface to the First Edition; Preface to the Second Edition; List of Symbols; 1 Structural Basis of Movement Across Cell Membranes; 1.1 Membrane Structure: Electron Microscopy of Biological Membranes; 1.2 Chemical Composition of Biological Membranes; 1.2.1 Membrane Lipids; 1.2.2 Membrane Proteins; 1.2.3 Membrane Carbohydrates; 1.3 Membrane Phospholipid Structures and Their Self-Assembly; 1.4 Phase Transitions in Biological Membranes; 1.5 Membrane Proteins: Their Structure and Arrangement1.5.1 Proteins That Span the Membrane Only Once1.5.2 Proteins That Span the Membrane More Than Once; 1.6 Synthesis of Membrane Proteins; 1.7 Quantitation of Membrane Dynamics; 1.8 Traffic Across the Plasma Membrane; 1.9 The Cell Membrane as a Barrier and as a Passage; Suggested Readings; General; Membrane Structure; Membrane Lipids; Liposomes; Membrane Proteins; Membrane Dynamics; Glycophorin; Lactose Permease; Hydropathy Plots; Membrane Protein Structure; Synthesis of Membrane Proteins; Endocytosis, Membrane Turnover; Clathrin-Coated Pits and Caveolae; Lipid Rafts; Cytoskeleton2 Simple Diffusion of Nonelectrolytes and Ions2.1 Diffusion as a Random Walk; 2.2 The Electrical Force Acting on an Ion; 2.3 Permeability Coefficients and Partition Coefficients; 2.4 Measurement of Permeability Coefficients; 2.5 Analysis of Permeability Data; 2.6 The Membrane as a Hydrophobic Sieve; 2.7 Osmosis and the Diffusion of Water; 2.8 Comparison of Osmotic and Diffusive Flow of Water; Suggested Readings; General; Diffusion as a Random Walk; Chemical Potential; Electrical Potential; Flux Ratio Test; Permeability and Partition Coefficients; Measurement of Permeability CoefficientsNMR and ESRUnstirred Layers; Plant Cell Permeabilities; Membrane as a Hydrophobic Sieve; Osmosis and the Diffusion of Water; Water Channels - The Aquaporins; Electroosmosis and Streaming Potential; 3 Ion Channels Across Cell Membranes; 3.1 The Gramicidin Channel; 3.2 The Acetylcholine Receptor Channel; 3.3 Conductances and Cross-Sectional Areas of Single Channels; 3.4 An Experimental Interlude; 3.4.1 Identification of Channels by Patch-Clamping; 3.4.2 Measurements of Membrane Potential by Using Intracellular Microelectrodes or by Following Dye Distribution3.5 Diffusion Potentials: Goldman-Hodgkin-Katz Equation3.6 Regulation and Modulation of Channel Opening; 3.6.1 The Potassium Channel of Sarcoplasmic Reticulum; 3.6.2 Sodium and Potassium Channels of Excitable Tissue; 3.6.3 The Cell-to-Cell Channel or Gap Junction; 3.6.4 Regulation and Modulation of Some Other Channels; Suggested Readings; Internet Resources; General; Electrostatic (Born) Free Energy; Gramicidin Channel; Enzyme Kinetics; Acetylcholine Receptor; Cloning and Molecular Biology; Acetylcholine Receptor Structure; Ionic Diffusion; Ligand-gated Ion ChannelsCharge Effects on Channel Conductance An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in Biological transportRegulationSoftwareBiological transport, ActiveLaboratory manualsElectronic books.Biological transportRegulationBiological transport, Active572.696Stein Wilfred D.91351Litman ThomasMiAaPQMiAaPQMiAaPQBOOK9910459797303321Channels, carriers, and pumps2160831UNINA04041nam 2200697 a 450 991078941830332120200520144314.01-283-13337-797866131333731-4008-3731-610.1515/9781400837311(CKB)2670000000095256(EBL)713600(OCoLC)730151760(SSID)ssj0000521975(PQKBManifestationID)11336234(PQKBTitleCode)TC0000521975(PQKBWorkID)10524184(PQKB)11190258(OCoLC)773584591(MdBmJHUP)muse43174(DE-B1597)453600(OCoLC)979749575(DE-B1597)9781400837311(Au-PeEL)EBL713600(CaPaEBR)ebr10477123(CaONFJC)MIL313337(OCoLC)733057494(MiAaPQ)EBC713600(EXLCZ)99267000000009525620040630d2005 uy 0engur|n|---|||||txtccrDesigns on nature[electronic resource] science and democracy in Europe and the United States /Sheila JasanoffCourse BookPrinceton, N.J. Princeton University Pressc20051 online resource (391 p.)"Fourth printing, and first paperback printing, 2007."0-691-11811-6 0-691-13042-6 Includes bibliographical references and index.Why compare? -- Controlling narratives -- A question of Europe -- Unsettled settlements -- Food for thought -- Natural mothers and other kinds -- Ethical sense and sensibility -- Making something of life -- The new social contract -- Civic epistemology -- Republics of science.Biology and politics have converged today across much of the industrialized world. Debates about genetically modified organisms, cloning, stem cells, animal patenting, and new reproductive technologies crowd media headlines and policy agendas. Less noticed, but no less important, are the rifts that have appeared among leading Western nations about the right way to govern innovation in genetics and biotechnology. These significant differences in law and policy, and in ethical analysis, may in a globalizing world act as obstacles to free trade, scientific inquiry, and shared understandings of human dignity. In this magisterial look at some twenty-five years of scientific and social development, Sheila Jasanoff compares the politics and policy of the life sciences in Britain, Germany, the United States, and in the European Union as a whole. She shows how public and private actors in each setting evaluated new manifestations of biotechnology and tried to reassure themselves about their safety. Three main themes emerge. First, core concepts of democratic theory, such as citizenship, deliberation, and accountability, cannot be understood satisfactorily without taking on board the politics of science and technology. Second, in all three countries, policies for the life sciences have been incorporated into "nation-building" projects that seek to reimagine what the nation stands for. Third, political culture influences democratic politics, and it works through the institutionalized ways in which citizens understand and evaluate public knowledge. These three aspects of contemporary politics, Jasanoff argues, help account not only for policy divergences but also for the perceived legitimacy of state actions.Democracy and scienceEuropeDemocracy and scienceUnited StatesDemocracy and scienceDemocracy and science338.9/2602.02bcl58.30bclJasanoff Sheila265884MiAaPQMiAaPQMiAaPQBOOK9910789418303321Designs on nature26376UNINA