06127nam 22007092 450 991045977630332120151005020623.01-107-21901-91-280-77582-30-511-91811-997866136862130-511-91713-90-511-91909-30-511-78129-60-511-91532-2(CKB)2670000000078952(EBL)585386(OCoLC)784881172(SSID)ssj0000468431(PQKBManifestationID)11291419(PQKBTitleCode)TC0000468431(PQKBWorkID)10506697(PQKB)11503480(UkCbUP)CR9780511781292(MiAaPQ)EBC585386(Au-PeEL)EBL585386(CaPaEBR)ebr10447275(CaONFJC)MIL368621(EXLCZ)99267000000007895220100519d2011|||| uy| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierDiagnostic pediatric hematopathology /edited by Maria A. Proytcheva[electronic resource]Cambridge :Cambridge University Press,2011.1 online resource (xi, 577 pages) digital, PDF file(s)Title from publisher's bibliographic system (viewed on 05 Oct 2015).0-521-88160-9 Includes bibliographical references and index.Cover; Diagnostic Pediatric Hematopathology; Title; Copyright; Dedication; Contents; Contributors; Acknowledgements; Introduction; Section 1: General and non-neoplastic hematopathology; Chapter 1: Hematologic values in the healthy fetus, neonate, and child; Developmental hematopoiesis: a general view; Composition of fetal blood; Hematologic values in term neonates and infants; Hematologic values in small-for-gestational-age (SGA) term newborns; Hematologic values in preterm neonates; Hematologic values during early childhood and in older childrenPreanalytical issues related to pediatric blood samplesLimited blood availability; Effect of blood sampling site on the hematology test results; Effect of exertion and violent crying on the white blood cell count; Other preanalytical factors affecting hematologic test results in neonates; Analytical issues related to pediatric blood samples; Interpretation of hematologic test results in children; Other factors affecting neonatal testing; Chapter 2: Normal bone marrow; Ontogeny of the hematopoietic system; Postnatal bone marrow; Age-specific differences in the bone marrowBone marrow examination in childrenReferences; Chapter 3: Disorders of erythrocyte production: Nutritional deficiencies, iron deficient, and sideroblastic anemia; Introduction; Iron; Dietary iron; Iron transport; Iron uptake from the intestine; Iron uptake from the plasma; Iron storage; Iron regulation; Hemoglobin synthesis; Age and iron needs; Iron in the first year; Iron in the diet; Assessment of iron status; Ferritin; Serum iron and transferrin; Zinc protoporphyrin; Soluble transferrin receptor; Treatment of iron deficiency; Vitamin B12; Role in the body; Dietary vitamin B12Vitamin B12 absorption and metabolismVitamin B12 deficiency; Maternal vitamin B12 deficiency; Inherited disorders of transport and absorption of vitamin B12; Inborn errors of metabolism; Methylmalonyl-CoA mutase deficiency; Adenosylcobalamin deficiency; Methylcobalamin deficiency; Combined deficiencies; Acquired vitamin B12 deficiency; Assessment; Treatment; Folate; Role in the body; Dietary folate and folic acid; Folate absorption and metabolism; Folate deficiency; Pregnancy; Malabsorption; Increased utilization of folate; Drugs; Inherited disorders of transport and metabolism; AssessmentTreatmentSideroblastic anemia; References; Chapter 4: Disorders of hemoglobin synthesis: Thalassemias and structural hemoglobinopathies; Normal hemoglobins; Structure and function of hemoglobin; Genetics and transcription control of hemoglobin; Disorders of hemoglobin synthesis; Overview; Population genetics; Thalassemias; Alpha-thalassemias; Beta-thalassemias; Delta-beta-thalassemias; Structural hemoglobinopathies; Hemoglobin S; Hemoglobin C, hemoglobin D, and other rare hemoglobinopathies; Interactions of structural hemoglobinopathies with thalassemias; Laboratory evaluation; IntroductionEffects of hemoglobinopathies on general laboratory testsDiagnostic Pediatric Hematopathology is unique in providing an accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood. The text discusses the development of the hematopoietic and lymphoid systems - and how this affects normal and abnormal findings in children at various ages. Also examined are the morphologic, immunophenotypic, cytogenetic, and molecular genetic characteristics of most pediatric-specific hematologic diseases. This is an excellent reference that ensures accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph nodes of children. The text is written by a team of experienced pediatric hematopathologists and clinical scientists drawn from major academic children's hospitals in the United States, Europe, and Canada. It will be a valuable tool in the every day practice of pathologists, pediatric pathologists, and hematopathologists, and a ready educational resource for fellows, pathology residents, medical students, clinical scientists in the field, and pediatric hematologists/oncologists.Pediatric hematologyBloodDiseasesDiagnosisChildrenDiseasesDiagnosisPediatric hematology.BloodDiseasesDiagnosis.ChildrenDiseasesDiagnosis.618.9215Proytcheva Maria A.UkCbUPUkCbUPBOOK9910459776303321Diagnostic pediatric hematopathology2492422UNINA