01864nam 2200529 450 991045973460332120200520144314.01-62036-069-1(CKB)3710000000380275(EBL)3037641(SSID)ssj0001461959(PQKBManifestationID)12577229(PQKBTitleCode)TC0001461959(PQKBWorkID)11478259(PQKB)11576170(MiAaPQ)EBC3037641(Au-PeEL)EBL3037641(CaPaEBR)ebr11035809(OCoLC)923700166(EXLCZ)99371000000038027520131216h20142014 uy| 0engur|n|---|||||txtccrHigher education at risk strategies to improve outcomes, reduce tuition, and stay competitive in a disruptive environment /Sandra Featherman ; foreword by Stephen Joel TrachtenbergSterling, Virgina :Stylus Publishing,[2014]©20141 online resource (265 p.)Description based upon print version of record.1-62036-067-5 Includes bibliographical references and index.Higher education at risk -- Nonprofit colleges: strengths and weaknesses -- Why college costs are so high -- How the for-profits do it -- Case studies, opportunities, and challenges -- Some prescriptions for higher education.College costsUnited StatesElectronic books.College costs378.3/8Featherman Sandra954376Trachtenberg Stephen JoelMiAaPQMiAaPQMiAaPQBOOK9910459734603321Higher education at risk2158623UNINA03225nam 2200433z- 450 991013679690332120231214133608.0(CKB)3710000000631153(oapen)https://directory.doabooks.org/handle/20.500.12854/53258(EXLCZ)99371000000063115320202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMetals and neurodegeneration: Restoring the balanceFrontiers Media SA20161 electronic resource (132 p.)Frontiers Research Topics2-88919-739-5 Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.Metals and neurodegenerationBrainneurodegenerative diseaseNeuronsMetalsIronCopperAlzheimer's diseaseZincManganeseKatja M. Kanninenauth1331569Anthony R. WhiteauthPeter J. CrouchauthBOOK9910136796903321Metals and neurodegeneration: Restoring the balance3040441UNINA