04385nam 2200745 450 991045970790332120200520144314.00-8122-9047-X10.9783/9780812290479(CKB)3710000000274867(OCoLC)896834181(CaPaEBR)ebrary10953818(SSID)ssj0001379310(PQKBManifestationID)11887597(PQKBTitleCode)TC0001379310(PQKBWorkID)11356009(PQKB)10857181(MiAaPQ)EBC3442434(OCoLC)899261616(MdBmJHUP)muse35426(DE-B1597)463547(OCoLC)959919065(DE-B1597)9780812290479(Au-PeEL)EBL3442434(CaPaEBR)ebr10953818(CaONFJC)MIL682659(OCoLC)932312992(EXLCZ)99371000000027486720141020h20152015 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierLearning to die in London, 1380-1540 /Amy ApplefordPhiladelphia, Pennsylvania :University of Pennsylvania Press,2015.©20151 online resourceMiddle Ages Series1-322-51377-5 0-8122-4669-1 Includes bibliographical references and index.Front matter --Contents --Note on Quotations --Introduction --Chapter 1. Spiritual Governance and the Lay Household: The Visitation of the Sick --Chapter 2. Dying Generations: The Dance of Death --Chapter 3. Self-Care and Lay Asceticism: Learn to Die --Chapter 4. Wounded Texts and Worried Readers: The Book of the Craft of Dying --Chapter 5. The Exercise of Death in Henrician England --Conclusion --Notes --Bibliography --Index --AcknowledgmentsTaking as her focus a body of writings in poetic, didactic, and legal modes that circulated in England's capital between the 1380's—just a generation after the Black Death—and the first decade of the English reformation in the 1530's, Amy Appleford offers the first full-length study of the Middle English "art of dying" (ars moriendi). An educated awareness of death and mortality was a vital aspect of medieval civic culture, she contends, critical not only to the shaping of single lives and the management of families and households but also to the practices of cultural memory, the building of institutions, and the good government of the city itself. In fifteenth-century London in particular, where an increasingly laicized reformist religiosity coexisted with an ambitious program of urban renewal, cultivating a sophisticated attitude toward death was understood as essential to good living in the widest sense. The virtuous ordering of self, household, and city rested on a proper attitude toward mortality on the part both of the ruled and of their secular and religious rulers. The intricacies of keeping death constantly in mind informed not only the religious prose of the period, but also literary and visual arts. In London's version of the famous image-text known as the Dance of Death, Thomas Hoccleve's poetic collection The Series, and the early sixteenth-century prose treatises of Tudor writers Richard Whitford, Thomas Lupset, and Thomas More, death is understood as an explicitly generative force, one capable (if properly managed) of providing vital personal, social, and literary opportunities.Middle Ages series.English literatureMiddle English, 1100-1500History and criticismDeath in literatureDeathEnglandLondonDeathEnglandLondonPsychological aspectsDeathPolitical aspectsEnglandLondonElectronic books.English literatureHistory and criticism.Death in literature.DeathDeathPsychological aspects.DeathPolitical aspects820.9/3548Appleford Amy1970-1034853MiAaPQMiAaPQMiAaPQBOOK9910459707903321Learning to die in London, 1380-15402454233UNINA04227nam 2200913z- 450 991067402010332120220111(CKB)5400000000042053(oapen)https://directory.doabooks.org/handle/20.500.12854/76444(oapen)doab76444(EXLCZ)99540000000004205320202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierToxin-Antitoxin Systems in Pathogenic BacteriaBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (170 p.)3-0365-0674-8 3-0365-0675-6 Bacterial toxin-antitoxin (TA) systems, which are ubiquitously present in bacterial genomes, are not essential for normal cell proliferation. The TA systems regulate fundamental cellular processes, facilitate survival under stress conditions, have essential roles in virulence and represent potential therapeutic targets. These genetic TA loci are also shown to be involved in the maintenance of successful multidrug-resistant mobile genetic elements. The TA systems are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition. Type II TA systems encode a labile antitoxin and its stable toxin; degradation of the antitoxin renders a free toxin, which is bacteriostatic by nature. A free toxin generates a reversible state with low metabolic activity (quiescence) by affecting important functions of bacterial cells such as transcription, translation, DNA replication, replication and cell-wall synthesis, biofilm formation, phage predation, the regulation of nucleotide pool, etc., whereas antitoxins are toxin inhibitors. Under stress conditions, the TA systems might form networks. To understand the basis of the unique response of TA systems to stress, the prime causes of the emergence of drug-resistant strains, and their contribution to therapy failure and the development of chronic and recurrent infections, must be known in order to grasp how TA systems contribute to the mechanisms of phenotypic heterogeneity and pathogenesis that will enable the rational development of new treatments for infections caused by pathogens.Medicinebicsscaddictionanti-addictionantibacterial agentsantibiotic resistanceantitoxinbacteriabacterial cell deathbacterial persistencebiofilmcell wall inhibitionclinical origincognate interactionscross-interactionscross-resistancecross-talkenvironmental originFst/Ldr familyKlebsiella pneumoniaeM. tuberculosismazFmolecular insulationmRNA interferasen/aNAD+nucleotide hydrolysisopportunistic pathogenpathogenesisPemI/PemKpersistenceprotein interfaceprotein-protein interactionssmall protein toxin structureStenotrophomonas maltophiliastress-responseTA systemstolerancetoxintoxin activationtoxin-antitoxintoxin-antitoxin systemtoxin-antitoxin systemtoxin-antitoxin systemstoxin-antitoxin systemstuberculosistype I toxin-antitoxin systemtype IIuridine diphosphate-N-acetylglucosamineX-ray crystallographyMedicineAlonso Juan Carlosedt1339342Alonso Juan CarlosothBOOK9910674020103321Toxin-Antitoxin Systems in Pathogenic Bacteria3060081UNINA