03570nam 2200601 450 991045960550332120200520144314.00-8131-6220-3(CKB)3710000000334447(EBL)1915650(SSID)ssj0001432714(PQKBManifestationID)11845927(PQKBTitleCode)TC0001432714(PQKBWorkID)11405624(PQKB)11693169(MiAaPQ)EBC1915650(OCoLC)761226484(MdBmJHUP)muse44677(Au-PeEL)EBL1915650(CaPaEBR)ebr11007405(CaONFJC)MIL691374(OCoLC)900345037(EXLCZ)99371000000033444720150128h19831983 uy 0engur|n|---|||||txtccrThe complete retirement handbook for anyone who will ever retire /Forest J. BowmanRevised edition.Lexington, Kentucky :The University Press of Kentucky,1983.©19831 online resource (249 p.)Includes index.1-322-60092-9 0-8131-5138-4 Cover; Title; Copyright; Contents; Acknowledgments; Preface; 1 It's Your Life-You Call the Shots; 2 Life Begins at Retirement; 3 Sun Belt, Here I Come! Moving After Retirement; 4 Your Retirement System-The Cornerstone of Your Planning; 5 Social Security-It's ""Social,"" but How Much ""Security""?; 6 Where There's a Will (or a Reasonable Substitute), There's a Way; 7 Probate (and How to Avoid It); 8 Living with a Revocable Living Trust; 9 Taxes-In General; 10 The Federal Estate Tax; 11 The Federal Income Tax; 12 The Federal Gift Tax; 13 Tax Shelters; 14 The Corporation-A ""Better Mousetrap""15 Putting Your Money to Work16 Life Insurance; 17 Putting It All Together; Appendices; A: Checklist for Apartment or Condominium; B: Special Housing Checklist for the Elderly; C: The Gap Between Postretirement Income and Expenses; D: Evaluating Your Pension Plan; E: State Requirements for a Valid Will; F: Devices for Avoiding Probate; G: State Individual Income Tax Rates; H: State Inheritance and Estate Taxes; I: Federal Individual Income Tax Rates; J: Federal Corporation Income Tax Rates; K: Computing Life Insurance Needs; L: Monthly Savings Needed to Reach Desired Amounts at RetirementGlossaryA; B; C; D; E; F; G; H; I; K; L; M; N; O; P; R; S; T; V; W; Z; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; V; WIf you are 20 or 30 years of age and just starting out in a career, this book can serve you as an excellent road map for your future retirement. If you are 40 to 50 years of age, this book can become the life-saver that can make your shortly-to-come retirement more full. If you are over 50 years of age, you need to rush out and get this book to keep from suffocating during your impending retirement. In other words, this book is an excellent volume for anyone who is in the American work force. The author begins the book with the basic premise that everyone who works for a living will one day reRetirementUnited StatesElectronic books.Retirement646.7/9Bowman Forest J.1054212MiAaPQMiAaPQMiAaPQBOOK9910459605503321The complete retirement handbook2486629UNINA05233nam 22007335 450 991029829170332120200630020701.01-4939-1010-810.1007/978-1-4939-1010-6(CKB)3710000000268118(EBL)1968543(OCoLC)908089680(SSID)ssj0001372157(PQKBManifestationID)11787373(PQKBTitleCode)TC0001372157(PQKBWorkID)11301328(PQKB)11006688(DE-He213)978-1-4939-1010-6(MiAaPQ)EBC1968543(PPN)182095347(EXLCZ)99371000000026811820141021d2015 u| 0engur|n|---|||||txtccrLasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds /by Yanyan Li, Séverine Zirah, Sylvie Rebuffat1st ed. 2015.New York, NY :Springer New York :Imprint: Springer,2015.1 online resource (113 p.)SpringerBriefs in Microbiology,2191-5385Description based upon print version of record.1-4939-1009-4 Includes bibliographical references.Overview on Lasso Peptide Research -- From the Producer Microorganisms to the Lasso Scaffold -- Biological Activities of Lasso Peptides and Structure-Activity Relationships -- Biosynthesis, Regulation and Export of Lasso Peptides -- Lasso Peptide Bioengineering and Bioprospecting.Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.SpringerBriefs in Microbiology,2191-5385Medical microbiologyImmunologyVaccinesMedical Microbiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B16003Immunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Vaccinehttps://scigraph.springernature.com/ontologies/product-market-codes/B16010Medical microbiology.Immunology.Vaccines.Medical Microbiology.Immunology.Vaccine.610615372616.9041616079Li Yanyanauthttp://id.loc.gov/vocabulary/relators/aut1061909Zirah Séverineauthttp://id.loc.gov/vocabulary/relators/autRebuffat Sylvieauthttp://id.loc.gov/vocabulary/relators/autMiAaPQMiAaPQMiAaPQBOOK9910298291703321Lasso Peptides2521365UNINA