02505oam 2200673I 450 991045925990332120200520144314.01-136-94510-51-136-94511-31-283-03730-097866130373050-203-84798-910.4324/9780203847985 (CKB)2560000000061569(EBL)668323(OCoLC)705930052(SSID)ssj0000470306(PQKBManifestationID)11300815(PQKBTitleCode)TC0000470306(PQKBWorkID)10413196(PQKB)11399032(MiAaPQ)EBC668323(Au-PeEL)EBL668323(CaPaEBR)ebr10452685(CaONFJC)MIL303730(EXLCZ)99256000000006156920180706d2011 uy 0engur|n|---|||||txtccrInformed by knowledge expert performance in complex situations /edited by Kathleen L. Mosier and Ute M. FischerNew York :Psychology Press,2011.1 online resource (433 p.)Expertise, research and applicationsBased on presentations from the 8th International Conference on Naturalistic Decision Making.1-138-97274-6 1-84872-911-1 Includes bibliographical references and indexes.pt. 1. Managing complexity : discussions from various fields and decision contexts -- pt. 2. Technological support and training for knowledge management -- pt. 3. Commentary : overlooked issues in expert decision making -- pt. 4. Outlook : new methods and approaches.The focus of this book is on how experts adapt to complexity, synthesize and interpret information in context, and transform or ""fuse"" disparate items of information into coherent knowledge.Expertise, research and applications.Decision makingExpertiseElectronic books.Decision making.Expertise.003/.56Fischer Ute M914857Mosier Kathleen L914858International Conference on Naturalistic Decision Making(8th)MiAaPQMiAaPQMiAaPQBOOK9910459259903321Informed by knowledge2050163UNINA04651nam 22006015 450 991030018790332120200703025156.03-319-09915-910.1007/978-3-319-09915-6(CKB)3710000000291462(EBL)1965246(OCoLC)908083223(SSID)ssj0001386583(PQKBManifestationID)11799006(PQKBTitleCode)TC0001386583(PQKBWorkID)11374164(PQKB)11363818(DE-He213)978-3-319-09915-6(MiAaPQ)EBC1965246(PPN)183088379(EXLCZ)99371000000029146220141118d2015 u| 0engur|n|---|||||txtccrLeptin Regulation and Clinical Applications /edited by Sam Dagogo-Jack, MD1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (299 p.)Description based upon print version of record.3-319-09914-0 Includes bibliographical references at the end of each chapters and index.Discovery of leptin and elucidation of leptin gene expression -- Leptin receptors and mechanism of action -- Leptin interaction with brain orexigenic and anorexigenic pathways -- Measurement of circulating leptin and soluble leptin receptors -- Physiological and hormonal factors that influence leptin production -- Leptin, obesity and leptin resistance -- Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism -- Leptin in acute stress -- Leptin and the kidney -- Leptin, immune function, and inflammation -- Leptin and bone -- Leptin, cell cycle, and cancer -- Leptin, the autonomic nervous system, and hypertension -- Dynamic leptin secretion in obesity and diabetes -- Leptin therapy of congenital leptin deficiency -- Leptin therapy in people with normal leptin gene -- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance -- Leptin therapy in women with hypothalamic amenorrhea -- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans -- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases.Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.EndocrinologyMetabolismDisordersEndocrinologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33053Metabolic Diseaseshttps://scigraph.springernature.com/ontologies/product-market-codes/H33118Endocrinology.MetabolismDisorders.Endocrinology.Metabolic Diseases.610612.6616.39616.4Dagogo-Jack MD, Samedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910300187903321Leptin2522510UNINA