05349nam 22006614a 450 991045823820332120200520144314.01-281-07062-997866110706250-12-289632-70-08-054118-6(CKB)1000000000384343(EBL)319073(OCoLC)476114626(SSID)ssj0000245831(PQKBManifestationID)11234644(PQKBTitleCode)TC0000245831(PQKBWorkID)10179785(PQKB)10456664(MiAaPQ)EBC319073(PPN)182573206(Au-PeEL)EBL319073(CaPaEBR)ebr10206109(CaONFJC)MIL107062(EXLCZ)99100000000038434320011010d2002 uy 0engur|n|---|||||txtccrSignal transduction[electronic resource] /Bastien D. Gomperts, Peter E.R. Tatham, IJsbrand M. KramerSan Diego, Calif. Academic Pressc20021 online resource (441 p.)Description based upon print version of record.0-12-289631-9 Includes bibliographical references and index.Front Cover; Signal Transduction; Copyright Page; Contents; Preface; Chapter 1. Prologue: Signal transduction, origins and personalities; Transduction, the word and its meaning: one dictionary, different points of view; Hormones, evolution and history; Hormones: a definition; Neurotransmitters; Ergot; Receptors and ligands; Chapter 2. First messengers; Hormones; Binding of ligands to receptors; Chapter 3. Receptors; Adrenaline (again); a- and ß-adrenergic receptors; Acetylcholine receptors; Ion channel-linked receptors; The 7TM superfamily of G-protein linked receptorsReceptor-ligand interaction and receptor activationTransmitting signals into cells; Intracellular 7TM receptor domains and signal transmission; Adrenaline (yet again); Chapter 4. GTP-binding proteins and signal transduction; Nucleotides as metabolic regulators; GTP-binding proteins, G-proteins or GTPases; Ras proteins; Ras-GAPs; Essay: Activation of G-proteins without subunit dissociation; Chapter 5. Effector enzymes coupled to GTP-binding proteins: Adenylyl cyclase and phospholipase C; Adenylyl cyclase; Phospholipase C; Chapter 6. The regulation of visual transductionSensitivity of photoreceptorsPhotoreceptor mechanisms; Adaptation: calcium acts as a negative regulator; Photo-excitation of rhodopsin; Switching off the mechanism; A note on phototransduction in invertebrates; Chapter 7. Calcium and signal transduction; A new second messenger is discovered; Calcium and evolution; Distinguishing Ca2+ and Mg2+; Free, bound and trapped Ca2+; Cytosol Ca2+ is kept low; Detecting changes in cytosol Ca2+; Mechanisms that elevate cytosol Ca2+ concentration; The pattern of cytosol Ca2+ changes in single cells; Localization of intracellular second messengersChapter 8. Calcium signallingCalcium binding by proteins; Effects of elevated calcium; Paradigms of calcium signalling; Chapter 9. Phosphorylation and dephosphorylation: Protein kinases A and C; Protein phosphorylation as a switch in cellular functioning; cAMP and the amplification of signals; Protein kinase A; Protein kinase A and the regulation of transcription; Protein kinase A and the activation of ERK; Actions of cAMP not mediated by PKA; Protein kinase C; The protein kinase C family; Structural domains and activation of protein kinase CMultiple sources of DAG and other lipids to activate PKCDifferential localization of PKC isoforms; PKC anchoring proteins, STICKs, PICKs and RACKs; PKC and cell transformation; PKC and inflammation; Chapter 10. Growth factors: Setting the framework; Viruses and tumours; The discovery of NGF... and EGF; Platelet derived growth factor; Transforming growth factors; Problems with nomenclature; Essay: The cell cycle; Essay: Cancer and cell transformation; Chapter 11. Signalling pathways operated by receptor protein tyrosine kinases; The tyrosine kinase family; Tyrosine kinase-containing receptorsBranching of the signalling pathwaySignal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scienCellular signal transductionElectronic books.Cellular signal transduction.571.6Gomperts B. D1056431Tatham Peter E. R723856Kramer Ijsbrand M512673MiAaPQMiAaPQMiAaPQBOOK9910458238203321Signal transduction2490786UNINA05605nam 22005775 450 991074114410332120251008150440.03-031-30897-210.1007/978-3-031-30897-0(PPN)284165514(OCoLC)1394113934(MiAaPQ)EBC30706865(CKB)27994683600041(DE-He213)978-3-031-30897-0(MiFhGG)9783031308970(EXLCZ)992799468360004120230817d2023 u| 0engurcn#|||mna|atxtrdacontentcrdamediacrrdacarrierThe Palgrave Handbook of Left-Wing Extremism, Volume 1 /edited by José Pedro Zúquete1st ed. 2023.Cham :Springer International Publishing :Imprint: Palgrave Macmillan,2023.1 online resource (xxxv, 309 pages) illustrations (some colour)3-031-30896-4 Includes bibliographical references and index.Introduction José Pedro Zúquete -- SECTION I Conceptual/Empirical Issues -- 1. Left-wing Extremism: the conceptual dimension Uwe Backes -- 2. The Evolution of Left-Wing Extremism Garth Davies and Vanja Zdjelar -- 3. Radicalization and Left-Wing Extremism Katharina Krüsselmann and Daan Weggemans -- 4. Women in Left-Wing Extremism Irina Jugl and Daniel Kohler -- 5. Vanguardism and Left-Wing Extremism Phillip W. Gray -- 6. Left-Wing Extremism and Violence Ignacio Sánchez-Cuenca -- 7. Guerrilla and Cognitive Warfare in Transnational Leftwing Extremism Josh Vandiver -- 8. The Measurement of Left-Wing Extremist Attitudes Sebastian Jungkunz -- 9. Research Techniques in the Study of Left-Wing Extremism Arije Antinori -- SECTION II Manifestations of Left-Wing Extremism -- Europe -- 10. Germany Eckhard Jesse -- 11. France Isabelle Sommier -- 12. United Kingdom Luke March -- 13. Greece Lamprini Rori and Vasiliki Georgiadou -- 14. Spain Carles Viñas -- 15. Italy Francesco Marone -- 16. Scandinavia Jan Jämte, Måns Lundstedt, Magnus Wennerhag.“A first full-scale, remarkably broad conceptual and historical study of left-wing extremism. An indispensable reading in the field”. Azar Gat, Ezer Weitzman Professorial Chair, School of Political Science, Tel Aviv University, Israel “An essential reading for those serious about understanding the contemporary challenges faced by liberal representative democracy”. Professor Matt Goodwin, University of Kent, UK “This handbook breaks with the underestimation of a polymorphic phenomenon that can now be observed all over the world and promises to become an indispensable working tool and a precious source of reflection on the new world disorder.” Pierre-André Taguieff, Director of the Centre for Political Research at Sciences Po, Paris "A work of impressive originality, this remarkably comprehensive book is badly needed, providing broad comparative perspective and objective analysis of the extreme left around the world. It will be an indispensable handbook not merely for scholars but also for all those interested in contemporary affairs, for it has no equal in the current literature." Professor Stanley Payne, Professor Emeritus of History at the University of Wisconsin–Madison, USA This handbook provides a broad overview of left-wing extremism and its associated key issues and themes. It breaks new ground by assembling in a single volume a comparative analysis of the phenomenon that is both multidimensional and multidisciplinary. Gathering a wide range of influential scholars who have worked at length in the field of extremism studies from different perspectives, backgrounds, and geographical settings, the Palgrave Handbook of Left-Wing Extremism presents an array of thought-provoking and innovative as well as informative analyses and discussions – both historical and contemporary – about the phenomenon of left-wing extremism and of how researchers conceive of and approach it in their study. The Handbook is designed to be, for the foreseeable future, the reference work for all students, researchers, and general readers interested in achieving a comprehensive understanding of left-wing extremism in all its manifestations, subtleties, and dynamics, and both its current and its potential directions. José Pedro Zúquete is Research Fellow at the Social Sciences Institute of the University of Lisbon, Portugal. He is the author of Missionary Politics in Contemporary Europe (2007), The Struggle for the World (co-authored with Charles Lindholm, 2010), and The Identitarians (2018). Chapter “Radical Left Movements in Scandinavia, 1980–2020: Straddling Militant Counterculture and Popular Movements” is available open access under a Creative Commons Attribution 4.0 International License via SpringerLink.International relationsPolitical sociologyCriminologyInternational Relations TheoryPolitical SociologyCrime Control and SecurityInternational relations.Political sociology.Criminology.International Relations Theory.Political Sociology.Crime Control and Security.320.5320.53Zúquete José PedroMiAaPQMiAaPQMiAaPQ9910741144103321The Palgrave handbook of left-wing extremism3598296UNINA