03364nam 2200709 a 450 991045403450332120200520144314.066120706171-282-07061-497866120706171-4416-0553-3600-00-1261-61-60750-391-3(CKB)1000000000723326(EBL)433455(OCoLC)608623513(SSID)ssj0000343821(PQKBManifestationID)11272824(PQKBTitleCode)TC0000343821(PQKBWorkID)10291793(PQKB)10665665(MiAaPQ)EBC433455(Au-PeEL)EBL433455(CaPaEBR)ebr10285492(CaONFJC)MIL207061(EXLCZ)99100000000072332620090514d2008 uy 0engur|n|---|||||txtccrTowards drugs of the future[electronic resource] key issues in lead finding and lead optimization /edited by C.G. Kruse and H. TimmermanAmsterdam IOS Press20081 online resource (140 p.)Solvay Pharmaceuticals Conferences,1566-7685 ;v. 9Description based upon print version of record.1-58603-949-0 Includes bibliographical references and index.Title page; Preface; List of Contributors; Contents; Conference Preface and Keynote Lecture; A Thermodynamic Platform for Drug Discovery and Optimization; Structure-Based Design: Past, Present, and Future; Sense and Nonsense in Drug Discovery: A Chemical Perspective; Synthesis at the Interface of Chemistry and Biology: How and Why?; Drug Design with ADME in Mind: Recent Paradigm Shifts in Drug Discovery; Hypothesis Generation for Scientific Discovery. Examples from the Use of KEM®, a Rule-Based Method for Multi-Objective Analysis and OptimizationDoes Size Matter? Facts and Thoughts on Recombinant DrugsCan Nanotechnology Improve the Oral Delivery of Therapeutic Proteins?; The Omeprazole Story: How Endurance in Research May Pay Off; Conceptual Design of Cannabinoid CB1 Receptor Antagonists; Author IndexThe number of novel medications in the global industry pipeline is insufficient to suffice demand of the markets, the financial performance of several companies is declining, and sales and marketing costs are rising. This title addresses the development in synthetic and medicinal chemistry with the emphasis on global challenges.Solvay Pharmaceuticals Conferences ;v. 9.Pharmaceutical chemistryCongressesDrug developmentCongressesPharmaceutical industryCongressesElectronic books.Pharmaceutical chemistryDrug developmentPharmaceutical industry615.1072Kruse C. G(Chris G.),1952-927044Timmerman H(Hendrick)91935Solvay Pharmaceuticals.Solvay Pharmaceutical Conference on Medicinal ChemistryMiAaPQMiAaPQMiAaPQBOOK9910454034503321Towards drugs of the future2082696UNINA