02939nam 2200649 450 991045377280332120200520144314.01-119-95207-71-118-52607-41-118-52601-51-118-52606-6(CKB)2550000001256700(EBL)1662189(SSID)ssj0001180119(PQKBManifestationID)11707588(PQKBTitleCode)TC0001180119(PQKBWorkID)11199478(PQKB)11649907(MiAaPQ)EBC1662189(MiAaPQ)EBC4036073(DLC) 2013049079(Au-PeEL)EBL1662189(CaPaEBR)ebr10856814(OCoLC)875820294(EXLCZ)99255000000125670020140414h20142014 uy 0engur|n|---|||||txtccrMolecular and cellular toxicology an introduction /Dr. Lesley A. StanleyChichester, England :Wiley Blackwell,2014.©20141 online resource (435 p.)Description based upon print version of record.1-119-95206-9 1-306-57172-3 Includes bibliographical references at the end of each chapters and index.Background to molecular and cellular toxicology -- Individual susceptibility to toxic chemicals -- Omics techniques -- In vitro methods for predicting in vivo toxicity -- In vitro methods for absorption, distribution, metabolism and excretion -- In silico methods and structure-activity relationships -- Transgenic animal models for ADME and systemic toxicity -- Genotoxicity and its measurement -- Oncogenes and the identification of human carcinogens -- Emerging techniques. Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects. Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift which Toxicity TestsMethodsMolecular biologyXenobioticstoxicityElectronic books.Toxicity TestsMolecular biology.Xenobioticstoxicity.615.9/07Stanley Lesley898450MiAaPQMiAaPQMiAaPQBOOK9910453772803321Molecular and cellular toxicology2007407UNINA