05597nam 2200721Ia 450 991045354960332120200520144314.01-281-90896-79786611908966981-270-713-1(CKB)1000000000552299(EBL)1214939(SSID)ssj0000292367(PQKBManifestationID)12068780(PQKBTitleCode)TC0000292367(PQKBWorkID)10268886(PQKB)10443975(MiAaPQ)EBC1214939(WSP)00005998(Au-PeEL)EBL1214939(CaPaEBR)ebr10698812(CaONFJC)MIL190896(OCoLC)854973185(EXLCZ)99100000000055229920060911d2006 uy 0engurcn|||||||||txtccrComputer simulation of shaped charge problems[electronic resource] /Wen Ho LeeSingapore ;Hackensack, NJ World Scientificc20061 online resource (220 p.)Description based upon print version of record.981-256-623-6 Includes bibliographical references and indexes.Contents; A Personal Introduction; Chapter 1 Small Molecules for Chemogenomics-based Drug Discovery Edgar Jacoby, Ansgar Schuffenhauer, Kamal Azzaoui, Maxim Popov, Sigmar Dressler, Meir Glick, Jeremy Jenkins, John Davies and Silvio Roggo; 1. Introduction; 2. Compound Categories; 2.1. Natural products and derivatives; 2.2. Primary metabolites, co-substrates, co-factors, and marketed drugs; 2.3. Peptides and peptido-mimetics; 2.4. Diversity oriented synthesis molecules; 3. Designing Comprehensive Chemogenomics Screening Compound Collections4. Essential Properties and Selection Processes along the Discovery Pipeline5. Molecular Information Systems and Annotated Compound Libraries; 6. Conclusion; Acknowledgements; References; Chapter 2 Mapping the Chemogenomic Space Jordi Mestres; 1. The Chemogenomic Space; 2. Annotation and Classification Schemes for Proteins; 2.1. Enzymes; 2.2. Receptors; 2.2.1. Channel receptors; 2.2.2. G Protein-coupled receptors; 2.2.3. Nuclear receptors; 3. Structural Representativity of Protein Families; 4. Annotation and Classification Schemes for Molecules; 5. Mapping the Molecule-Protein Space6. Exploiting the Chemogenomic Space 7. Conclusions; References; Chapter 3 Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development Frank J. Dekker, Stefan Wetzel and Herbert Waldmann; 1. Introduction; 2. Biological Relevance in Compound Library Design; 2.1. Compound libraries as sources for small molecule modulators of protein function; 2.2. Annotated libraries; 2.3. Natural products as inspiration sources for library design; 2.4. Library design based on privileged structures3. Natural Product Inspired Compound Library Synthesis 4. Target Clustering as Strategy in Drug Discovery; 4.1. Target clustering; 4.2. Target clustering based on structural and functional similarity; 5. PSSC as Guiding Principle for Compound Library Design; 5.1. Protein structure similarity clustering (PSSC); 5.2. PSSC based reanalysis of the development of leukotriene A4 hydrolase inhibitors; 5.3. PSSC based reanalysis of the development of nuclear hormone receptor ligands5.4. Application of PSSC for de novo ligand development for the protein cluster Cdc25A phosphataseacetylcholinesterase-11β-hydroxysteroid dehydrogenase5.5. Position of the PSSC concept in drug development and chemogenomics; 6. Conclusions; Acknowledgments; References; Chapter 4 A Reductionist Approach to Chemogenomics in the Design of Drug Molecules and Focused Libraries Roger Crossley and Martin Slater; 1. Introduction; 2. Molecular Recognition and Vicinity AnalysisTM; 3. Thematic AnalysisTM; Examples of Themes; 4. Family B and C GPCRs; 5. Classification of GPCRs; 6. Pharmacophore Maps7. Library Design Using Thematic AnalysisTMDevoted to the subject of shape charge design using numerical methods, this book offers the defense and commercial industries unique material not contained in any other single volume. The coverage of the Lagrangian and Eulerian methods as well as the equation of state provides first hand help to engineers working on shape charge problems.The book includes detailed descriptions of oil-well perforation not available from any other sources and, coupled with the material flow physics discussed in Chapters 2 and 3 and Appendix B, readers can design the fuel rod configurations for a nuclear reactorShaped chargesComputer simulationShaped chargesMathematical modelsFlow visualizationComputer simulationPenetration mechanicsComputer simulationLagrange equationsElectronic books.Shaped chargesComputer simulation.Shaped chargesMathematical models.Flow visualizationComputer simulation.Penetration mechanicsComputer simulation.Lagrange equations.623.4/545Lee Wen Ho948126MiAaPQMiAaPQMiAaPQBOOK9910453549603321Computer simulation of shaped charge problems2143102UNINA04022nam 22005415 450 991084185390332120251113174004.03-031-51485-810.1007/978-3-031-51485-2(CKB)30597448200041(MiAaPQ)EBC31200801(Au-PeEL)EBL31200801(DE-He213)978-3-031-51485-2(EXLCZ)993059744820004120240225d2024 u| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrier12th Asian-Pacific Conference on Medical and Biological Engineering Proceedings of APCMBE 2023, May 18–21, 2023, Suzhou, China—Volume 2: Computer-Aided Surgery, Biomechanics, Health Informatics, and Computational Biology /edited by Guangzhi Wang, Dezhong Yao, Zhongze Gu, Yi Peng, Shanbao Tong, Chengyu Liu1st ed. 2024.Cham :Springer Nature Switzerland :Imprint: Springer,2024.1 online resource (439 pages)IFMBE Proceedings,1433-9277 ;1043-031-51484-X Inside-out Accurate Head Tracking with Head-mounted Augmented Reality Device -- A Model-guided Method for Ultrasound Probe Calibration -- Real-time Medical Tool Runout Monitor Based on Dual Laser Displacement Sensors -- Correction of Premature Closure of Sagittal Suture with Small-incision Traction Bow -- A Home-style Intelligent Monitoring Sanitize Robot -- Yolov7-based Multiple Surgical Tool Localization and Detection in Laparoscopic Videos -- A Frequency-based Analysis Method to Improve Adversarial Robustness of Neural Networks for EEG-based Brain-computer Interfaces -- Robot-assisted Optical Coherence Tomography for Automatic Wide-field Scanning -- Adversarial Detection and Defense for Medical Ultrasound Images: From a Frequency Perspective -- A Novel Model-independent Approach for Autonomous Retraction of Soft Tissue -- A Soft Robot Using Magnetic-pneumatic Hybrid Actuation That Functions in Unstructured Environments -- A VR Environment for Cervical Tumor Segmentation Though Three-dimensional Spatial Interaction -- An Image Fusion Method Combining the Advantages of Dual-mode Optical Imaging in Endoscopy -- An End-to-end Spatial-temporal Transformer Model for Surgical Action Triplet Recognition -- 2D/3D Reconstruction of Patient-specific Surface Models and Uncertainty Estimation via Posterior Shape Models.This book presents cutting-edge research and developments in the field of medical and biological engineering, which a special emphasis on activities carried out in the Asian-Pacific region. Gathering the proceedings of the 12th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE 2023), held on May 18–21, 2023, in Suzhou, China, this second volume of a two-volume set covers advances in computer-aided surgery, biomechanics and micro-nanoengineering, health informatics and health engineering, as well as computational modeling and simulation, as well as AI applications in biology and medicine. It addresses a broad audience of researchers and professionals active in biomedical engineering, biomechanics, medical biophysics, and health informatics.IFMBE Proceedings,1433-9277 ;104Biomedical engineeringBiophysicsBiomedical Devices and InstrumentationBioanalysis and BioimagingMedical and Health TechnologiesBiomedical engineering.Biophysics.Biomedical Devices and Instrumentation.Bioanalysis and Bioimaging.Medical and Health Technologies.610.28Wang GuangzhiMiAaPQMiAaPQMiAaPQBOOK991084185390332112th Asian-Pacific Conference on Medical and Biological Engineering4260031UNINA