03739oam 22007334a 450 991045277960332120211004152522.00-691-16847-41-4008-4846-610.1515/9781400848461(CKB)2550000001125726(EBL)1329785(SSID)ssj0001001028(PQKBManifestationID)12394589(PQKBTitleCode)TC0001001028(PQKBWorkID)10966637(PQKB)11448522(MiAaPQ)EBC1329785(StDuBDS)EDZ0000142002(DE-B1597)474190(OCoLC)1004867046(DE-B1597)9781400848461(PPN)199244251(OCoLC)1273306595(MdBmJHUP)musev2_77334(EXLCZ)99255000000112572620150921e20162013 uy 0engur|nu---|u||utxtccrThe Alzheimer ConundrumEntanglements of Dementia and Aging /Margaret LockCourse BookPrinceton :Princeton University Press,2016.©2016.1 online resource (323 p.)Originally published: 2013.0-691-14978-X 1-299-95116-3 Includes bibliographical references and index.Acknowledgments -- Orientations -- Making and remaking Alzheimer disease -- Striving to standardize Alzheimer disease -- Paths to Alzheimer prevention -- Embodied risk made visible -- Alzheimer genes: biomarkers of prediction and prevention -- Genome-wide association studies: back to the future -- Living with embodied omens -- Chance untamed and the return of fate -- Transcending entrenched tensions -- Portraits from the mind -- Notes -- Bibliography -- Index.Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer's disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer's disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.Older peopleMental healthfast(OCoLC)fst01199117BrainAgingMolecular aspectsfast(OCoLC)fst00837576Alzheimer's diseaseAge factorsfast(OCoLC)fst01750368BrainAgingMolecular aspectsOlder peopleMental healthAlzheimer's diseaseAge factorsElectronic books. Older peopleMental health.BrainAgingMolecular aspects.Alzheimer's diseaseAge factors.BrainAgingMolecular aspects.Older peopleMental health.Alzheimer's diseaseAge factors.362.1968/31Lock Margaret M.1009391MdBmJHUPMdBmJHUPBOOK9910452779603321The Alzheimer conundrum2463738UNINA05028nam 22014293a 450 991036774940332120250203235425.09783039216079303921607410.3390/books978-3-03921-607-9(CKB)4100000010106223(oapen)https://directory.doabooks.org/handle/20.500.12854/55429(ScCtBLL)f5f181b3-8184-4ce2-932b-bcaa44d59d32(OCoLC)1163808624(oapen)doab55429(EXLCZ)99410000001010622320250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe origin and Early Evolution of Life : Prebiotic Chemistry of Biomolecules /Michele FioreMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (288 p.)9783039216062 3039216066 Studying the origin of life is one of man's greatest achievements over the last sixty years. The fields of interest encompassed by this quest are multiple and interdisciplinary: chemistry, physics, biology, biochemistry, mathematics, geology but also statistics, atmospheric science, meteorology, oceanography, and astrophysics. Recent scientific discoveries, such as water on Mars and the existence of super-Earths with atmospheres similar to primordial Earth, have pushed researchers to simulate prebiotic conditions in explaining the abiotic formation of molecules essential to life. This collection of articles offers an overview of recent discoveries in the field of prebiotic chemistry of biomolecules, their formation and selection, and the evolution of complex chemical systems.Chemistrybicsscmineralsinosinecarbamic acidprebiotic chemistrypentopyranose nucleic acidcatalysisMVC architecture pattern and biological informationcarbon dioxide-ammonia icesstability as a selection pressureribozyme and tRNAtranslation and the genetic codeAnyLogic software for computer simulation of translation machineDarwinian evolutionprebiotic information systemgenetic code originelectrochemistrycoevolution of translation machine and the genetic codedigit multiplicitythermodynamic bottleneckabasic oligomersselectionnucleotide stabilityAICARtRNA-synthetasehypercyclenucleotide oligomerizationorigin of lifethioesterdry-wet cyclesChemomimesispopulation growthtRNA and mRNAdiversityearly peptidesMolecular DarwinismtRNA accretion modelreplicationaldol reactionhydrothermal ventsbase pairingnumerical codonsabiogenesispurine precursorpeptide/RNA worldinformationab initio molecular dynamicsRNAcysteinenucleotide and nucleoside synthesisthiol-rich peptidesnovel metalloproteinstransmissionfunctionenergy currencyanharmonicityarabinopyranose nucleic acidbridge peptide and aaRSaminonitrilesmechanochemistryprebiotic polymerizationorigins of lifeencodingcarbon fixationinfrared spectraphosphoryl transfermetabolismgrowth orderlayered double hydroxide (LDH) claymolecular clocksMonte Carlobinary patterned amino acid sequencesnetwork expansion simulationprebiotic soupnucleotidyltransferasesmixed anhydridephosphatestranslationribosomepentose diphosphatemonosaccharidessystems chemistryreductionimidazolesprotein designChemistryFiore Michele1312140ScCtBLLScCtBLLBOOK9910367749403321The Origin and Early Evolution of Life3038915UNINA