05085nam 2200637 a 450 991045269080332120200520144314.01-283-85621-20-19-165428-0(CKB)2550000000707366(EBL)1100081(OCoLC)821965264(SSID)ssj0000811604(PQKBManifestationID)12349368(PQKBTitleCode)TC0000811604(PQKBWorkID)10850675(PQKB)10605251(MiAaPQ)EBC1100081(Au-PeEL)EBL1100081(CaPaEBR)ebr10631208(CaONFJC)MIL416871(EXLCZ)99255000000070736620121210d2013 uy 0engur|n|---|||||txtccrPhysical principles in sensing and signaling[electronic resource] with an introduction to modeling in biology /Robert G. EndresOxford Oxford University Press20131 online resource (158 p.)Description based upon print version of record.0-19-960064-3 0-19-960063-5 Includes bibliographical references and index.Cover; Contents; 1 Introduction; Chapter summary; Further reading; 2 Chemotaxis in bacterium Escherichia coli; 2.1 Chemical gradient sensing; 2.2 "Nose and brain": the receptor cluster; 2.3 E. coli chemotaxis pathway; 2.4 Experimental approaches; 2.5 Time-course data and dose-response curves; Chapter summary; Further reading; 3 Physical concepts; 3.1 Diffusion; 3.2 Boltzmann distribution; 3.3 Ligand-receptor binding; 3.4 Fluctuation-dissipation theorem; Chapter summary; Further reading; 4 Mathematical tools; 4.1 Ordinary differential equations; 4.2 Kinetic laws; 4.3 Master equation4.4 Poisson distribution4.5 Waiting-time distribution; 4.6 Langevin small-noise approximation; 4.7 Information theory; Chapter summary; Further reading; 5 Signal amplification and integration; 5.1 Cooperativity by allostery; 5.2 Emergence of allostery from microscopic details; 5.3 Two-state equilibrium receptor model; 5.4 Monod-Wyman-Changeux model for receptor signaling; 5.5 Alternative Ising model for receptor cluster; Chapter summary; Further reading; 6 Robust precise adaptation; 6.1 Energy-landscape picture of adaptation; 6.2 Dynamics of adaptation; 6.3 Chemotactic response function6.4 Integral-feedback control6.5 Assistance neighborhoods; Chapter summary; Further reading; 7 Polar receptor localization and clustering; 7.1 Trimer of dimers; 7.2 Elastic cluster-membrane model; 7.3 Polar receptor clustering; Chapter summary; Further reading; 8 Accuracy of sensing; 8.1 Perfectly absorbing sphere; 8.2 Perfectly monitoring sphere; 8.3 Sensing with cell-surface receptors; Chapter summary; Further reading; 9 Motor impulse response; 9.1 Impulse response; 9.2 Time and frequency domains; 9.3 Minimal pathway model; 9.4 Linear response approximation; 9.5 Noise power spectraChapter summaryFurther reading; 10 Optimization of pathway; 10.1 Optimal receptor-complex size; 10.2 Optimal adaptation dynamics; Chapter summary; Further reading; 11 "Seeing like a bacterium"; 11.1 Typical chemical gradients; 11.2 Weber's law; 11.3 Perception; 11.4 Fold-change detection; 11.5 Matching relations; 11.6 Predicting typical stimuli; Chapter summary; Further reading; 12 Beyond E. coli chemotaxis; Chapter summary; Further reading; Appendix More techniques; A.1 Derivation of the fluctuation-dissipation theorem; A.2 Variational principles and the Euler-Lagrange equationA.3 Gillespie simulationsA.4 Fokker-Planck approximation; A.5 Derivation of the Langevin noise; A.6 Time versus frequency domain; A.7 Model fitting to data; A.8 Principal component analysis; Chapter summary; Further reading; Index; A; B; C; D; E; F; G; H; I; L; M; N; O; P; Q; R; S; T; V; WAlthough invisible to the bare eye, bacterial cells are large enough to make complex decisions. Cells are composed of thousands of different molecular species including DNA, proteins, and smaller molecules, allowing them to sense their environment, to process this information, and to respond accordingly. Such responses include expression of genes or the control of their movement. Despite these properties, a living cell exists in the physical world and follows its laws. Keeping thisin mind can help answer questions such as how cells work and why they implement solutions to problems the way theyBiologySimulation methodsBiologyMathematical modelsElectronic books.BiologySimulation methods.BiologyMathematical models.571.43571.634Endres Robert G239841MiAaPQMiAaPQMiAaPQBOOK9910452690803321Physical principles in sensing and signaling1970290UNINA