03927oam 2200697I 450 991045104290332120200520144314.00-429-07779-31-4822-8345-X1-280-05339-997866100533910-203-30361-X10.1201/9781482283457 (CKB)1000000000252010(EBL)181537(OCoLC)56909274(SSID)ssj0000282041(PQKBManifestationID)11232242(PQKBTitleCode)TC0000282041(PQKBWorkID)10316635(PQKB)10676856(MiAaPQ)EBC181537(Au-PeEL)EBL181537(CaPaEBR)ebr10097383(CaONFJC)MIL5339(OCoLC)560074402(EXLCZ)99100000000025201020180706d1998 uy 0engur|n|---|||||txtccrMolecular biology of Alzheimer's disease genes and mechanisms involved in amyloid generation /edited by Christian HaassAustralia :Harwood Academic Publishers, an imprint of Overseas Publishers Association,1998.1 online resource (350 p.)Description based upon print version of record.90-5702-381-4 Includes bibliographical references and index.Book Cover; Title; Contents; Contributors; Introduction; Amyloid Morphology and Pathology of Alzheimer's Disease; The Tau Proteins in Alzheimer's Disease; Mutations in Three Genes are Associated with Early Onset Alzheimer's Disease; The Biological Activities and Function of the Amyloid Precursor Protein of Alzheimer's Disease; Proteolytic Processing of the -Amyloid Precursor Protein; Biosynthesis of APP and A: Multiple Pathways for the Generation of Intracellular A; The Cell Biology of Amyloid Precursor ProteinThe Role of Amyloid -Peptide Terminating at Amino Acid 42 in Early Onset Alzheimer's DiseaseThe Biophysics of Amyloid -Protein Fibrillogenesis; The Molecular Biology of Presenilin 1; Molecular Biology of Presenilin 2; Presenilin Proteins and their Role in Development and Notch Signaling; The Processing of the Amyloid-Precursor-Protein (APP) in Presenilin-1 Deficient Neurons; Presenilins and their Role in Apoptosis; The Phosphorylation of Presenilin Proteins; APOE and its Role in Late Onset Alzheimer's DiseaseTransgenic Animal Models in the Development of Therapeutic Strategies for Alzheimer's DiseasePresenilins in Transgenic Mice; IndexHighlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, rAlzheimer's diseaseGenetic aspectsAlzheimer's diseaseMolecular aspectsAmyloid beta-protein precursorMolecular neurobiologyElectronic books.Alzheimer's diseaseGenetic aspects.Alzheimer's diseaseMolecular aspects.Amyloid beta-protein precursor.Molecular neurobiology.616.831Haass Christian876781MiAaPQMiAaPQMiAaPQBOOK9910451042903321Molecular biology of Alzheimer's disease1957964UNINA