03148oam 2200505 450 991044425430332120220630152146.0981-334-033-910.1007/978-981-33-4033-6(CKB)4100000011759619(DE-He213)978-981-33-4033-6(MiAaPQ)EBC6476035(PPN)253857295(EXLCZ)99410000001175961920210701d2020 uy 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierQuantitative physiology systems approach /Shangbin Chen, Alexey Zaikin1st ed. 2020.Singapore :Springer,[2020]©20201 online resource (XXI, 237 p. 246 illus., 97 illus. in color.)981-334-032-0 Introduction of Quantitative Physiology -- Systems and Modelling -- Relevant Resources -- Modelling Gene Expression -- Bone and Body Mechanics -- Blood Dynamics -- Metabolic Network -- Systems pharmacology -- Calcium Signalling -- Modelling Neural Activity -- Cortical Spreading Depression (CSD) -- Heart Physiome -- Constructing genetic intelligence -- Brain Project.Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics.PhysiologyMathematical modelsFisiologiathubModels matemàticsthubLlibres electrònicsthubPhysiologyMathematical models.FisiologiaModels matemàtics571.015118Chen Shangbin929066Zaikin AlexeyMiAaPQMiAaPQUtOrBLWBOOK9910444254303321Quantitative physiology2088034UNINA