04511nam 22007815 450 991043813440332120200705083656.01-283-63018-497866139426303-642-30331-510.1007/978-3-642-30331-9(CKB)2560000000090964(EBL)994563(OCoLC)808484299(SSID)ssj0000738913(PQKBManifestationID)11401797(PQKBTitleCode)TC0000738913(PQKBWorkID)10672983(PQKB)10300827(DE-He213)978-3-642-30331-9(MiAaPQ)EBC994563(PPN)168316447(EXLCZ)99256000000009096420120814d2013 u| 0engur|n|---|||||txtccrProspects for Chemoprevention of Colorectal Neoplasia[electronic resource] Emerging Role of Anti-Inflammatory Drugs /edited by Andrew T. Chan, Elmar Detering1st ed. 2013.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2013.1 online resource (185 p.)Recent Results in Cancer Research,0080-0015 ;191Description based upon print version of record.3-642-43447-9 3-642-30330-7 Includes bibliographical references.What is chemoprevention today?- Mechanistic aspects in tumor development and progression of colorectal adenoma and carcinoma -- Mode of action of  aspirin as a chemopreventive agent -- Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials -- COX-2 active agents in chemoprevention (includes aspirin, coxibs, and DFMO) -- New potential developments in aspirin/NSAID derivatives -- Aspirin in CRC chemoprevention in the context of other chronic diseases -- Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal adenoma and carcinoma -- Genetic risks for CRC and hereditary forms of CRC. – Strategies for prevention in high risk population.The prevention of colorectal cancer is a subject of increasing medical importance, and there have been a number of promising recent developments. This book examines in detail important aspects of the current status and future prospects for chemoprevention of colorectal tumors. Research into the mechanisms that lead from early colorectal adenoma to colorectal cancer is discussed. The role and modes of action of available drugs such as celecoxib and sulindac are described, and recent data from aspirin trials are analyzed. In addition, the possible impact of nutritional agents with anti-inflammatory properties is considered, and strategies applicable in those with a high level of genetic risk are evaluated. An important feature of the book is its holistic perspective, making it relevant for gastroenterologists, internists, general practitioners, oncologists, colorectal and gastroenterological surgeons, and public health practitioners.Recent Results in Cancer Research,0080-0015 ;191Oncology  Gastroenterology Internal medicineCardiologyRectum—Surgery Oncologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33160Gastroenterologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33061Internal Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/H33002Cardiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33037Colorectal Surgeryhttps://scigraph.springernature.com/ontologies/product-market-codes/H59036Oncology  .Gastroenterology .Internal medicine.Cardiology.Rectum—Surgery .Oncology.Gastroenterology.Internal Medicine.Cardiology.Colorectal Surgery.616.994347Chan Andrew Tedthttp://id.loc.gov/vocabulary/relators/edtDetering Elmaredthttp://id.loc.gov/vocabulary/relators/edtBOOK9910438134403321Prospects for Chemoprevention of Colorectal Neoplasia2230317UNINA