03419nam 2200589 a 450 991043813150332120200520144314.01-283-61246-197866139249190-85729-209-910.1007/978-0-85729-209-4(CKB)2670000000241321(EBL)972296(OCoLC)808814488(SSID)ssj0000739414(PQKBManifestationID)11458064(PQKBTitleCode)TC0000739414(PQKBWorkID)10688679(PQKB)10048119(DE-He213)978-0-85729-209-4(MiAaPQ)EBC972296(PPN)16828880X(EXLCZ)99267000000024132120120907d2013 uy 0engur|n|---|||||txtccrStroke genetics /Pankaj Sharma, James F. Meschia, editors1st ed. 2013.London Springer20131 online resource (332 p.)Description based upon print version of record.1-4471-6176-9 0-85729-208-0 Includes bibliographical references and index.Introduction -- Candidate Gene Association Studies in Stroke -- Genome-Wide Association Studies (GWAS) -- The Genetics of Cerebral Aneurysms and Other Vascular Malformations -- Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy -- Clinicogenetic and Pathologic Characteristics of CADASIL -- Monogenic Disorder: Fabry Disease -- Stroke-like Episodes in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) -- Genetics of Sickle Cell Disease and Stroke -- Other Monogenetic Stroke Disorders -- White Matter Disease -- Genetics of Carotid Disease -- Genetics of Cervical Artery Dissection -- Stroke Pharmacogenetics -- Ethical Issues in the Genetics of Complex Disorders.Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.   Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.Cerebrovascular diseaseGenetic aspectsCerebrovascular diseaseGenetic aspects.616.81042616.81042Sharma Pankaj769368Meschia James F1643698MiAaPQMiAaPQMiAaPQBOOK9910438131503321Stroke Genetics4156210UNINA