03256nam 2200577Ia 450 991043812950332120200520144314.01-4614-6561-310.1007/978-1-4614-6561-4(CKB)2550000001043728(EBL)1205334(SSID)ssj0000878511(PQKBManifestationID)11482771(PQKBTitleCode)TC0000878511(PQKBWorkID)10836549(PQKB)11722339(DE-He213)978-1-4614-6561-4(MiAaPQ)EBC1205334(PPN)16913640X(EXLCZ)99255000000104372820130410d2013 uy 0engur|n|---|||||txtccrAutophagy and cancer /Hong-Gang Wang, editor1st ed. 2013.New York, NY Springerc20131 online resource (261 p.)Current cancer research ;8Includes index.1-4899-9177-8 1-4614-6560-5 Preface -- Historical Overview of Autophagy -- The Core Molecular Machinery of Autophagosome Formation -- The origin of autophagosomes: The beginning of an end -- Signal Transduction Regulation of Autophagy -- Role of Autophagy in Tumorigenesis -- Selective autophagy and cancer -- Oncogenes and tumor suppressor genes in autophagy -- Autophagy and Immunity -- Autophagy and the Tumor Microenvironment -- Autophagy and Cancer Therapy -- The Crosstalk between Apoptosis & Autophagy -- Autophagy and Cancer Drug Discovery -- Index.This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer.Current cancer research ;8.CarcinogenesisCancerImmunological aspectsCarcinogenesis.CancerImmunological aspects.571.9571.9/36Wang Hong-Gang1755298MiAaPQMiAaPQMiAaPQBOOK9910438129503321Autophagy and cancer4192030UNINA