03393nam 2200649 a 450 991043799260332120200520144314.01-283-93366-71-4614-4741-010.1007/978-1-4614-4741-2(CKB)3400000000093719(EBL)1081854(OCoLC)822995930(SSID)ssj0000810373(PQKBManifestationID)11494962(PQKBTitleCode)TC0000810373(PQKBWorkID)10846306(PQKB)11322690(DE-He213)978-1-4614-4741-2(MiAaPQ)EBC1081854(PPN)168301083(EXLCZ)99340000000009371920121018d2013 uy 0engur|n|---|||||txtccrAdvances in DNA repair in cancer therapy /Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors1st ed. 2013.New York Springer20131 online resource (316 p.)Cancer drug discovery and developmentDescription based upon print version of record.1-4899-9308-8 1-4614-4740-2 Includes bibliographical references and index.Preface -- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy? -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy -- The role of BRCA1 and BRCA2 in anticancer drug therapy -- DNA-PK in CLL Chemotherapy -- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a Therapeutic Target -- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index.This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin.  The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1.  Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling  is examined.Cancer Drug Discovery and Development,2196-9906CancerTreatmentGenetic aspectsDNA repairCancerTreatmentGenetic aspects.DNA repair.616.99616.99/4061616.99406Panasci Lawrence1755709Aloyz Raquel1755710Alaoui-Jamali Moulay1755711MiAaPQMiAaPQMiAaPQBOOK9910437992603321Advances in DNA repair in cancer therapy4192614UNINA