03884nam 22007455 450 99646536620331620200718134150.0981-15-6648-810.1007/978-981-15-6648-6(CKB)4100000011354707(DE-He213)978-981-15-6648-6(MiAaPQ)EBC6272258(PPN)254727131(EXLCZ)99410000001135470720200718d2020 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierComputing Science, Communication and Security[electronic resource] First International Conference, COMS2 2020, Gujarat, India, March 26–27, 2020, Revised Selected Papers /edited by Nirbhay Chaubey, Satyen Parikh, Kiran Amin1st ed. 2020.Singapore :Springer Singapore :Imprint: Springer,2020.1 online resource (XV, 354 p. 179 illus., 147 illus. in color.) Communications in Computer and Information Science,1865-0929 ;1235981-15-6647-X Includes bibliographical references and index.Artificial Intelligence and Machine Learning -- Network, Communication and Security -- Computing Science. .This book constitutes revised selected papers of the First International Conference on Computing Science, Communication and Security, COMS2 2020, held in March 2020. Due to the COVID-19 pandemic the conference was held virtually. The 26 full papers and 1 short paper were thoroughly reveiwed and selected from 79 submissions. Papers are organised according to the topical sections on artificial intelligence and machine learning; network, communication and security; computing science.Communications in Computer and Information Science,1865-0929 ;1235Artificial intelligenceComputersComputer communication systemsArchitecture, ComputerApplication softwareEducation—Data processingArtificial Intelligencehttps://scigraph.springernature.com/ontologies/product-market-codes/I21000Information Systems and Communication Servicehttps://scigraph.springernature.com/ontologies/product-market-codes/I18008Computer Communication Networkshttps://scigraph.springernature.com/ontologies/product-market-codes/I13022Computer System Implementationhttps://scigraph.springernature.com/ontologies/product-market-codes/I13057Computer Appl. in Social and Behavioral Scienceshttps://scigraph.springernature.com/ontologies/product-market-codes/I23028Computers and Educationhttps://scigraph.springernature.com/ontologies/product-market-codes/I24032Artificial intelligence.Computers.Computer communication systems.Architecture, Computer.Application software.Education—Data processing.Artificial Intelligence.Information Systems and Communication Service.Computer Communication Networks.Computer System Implementation.Computer Appl. in Social and Behavioral Sciences.Computers and Education.016.403Chaubey Nirbhayedthttp://id.loc.gov/vocabulary/relators/edtParikh Satyenedthttp://id.loc.gov/vocabulary/relators/edtAmin Kiranedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK996465366203316Computing Science, Communication and Security1905224UNISA04560nam 22008295 450 991043789450332120251113211248.01-283-91007-13-642-34094-610.1007/978-3-642-34094-9(CKB)2670000000279790(EBL)1082770(OCoLC)821265731(SSID)ssj0000799152(PQKBManifestationID)11438348(PQKBTitleCode)TC0000799152(PQKBWorkID)10763945(PQKB)11454828(DE-He213)978-3-642-34094-9(MiAaPQ)EBC1082770(PPN)168326124(EXLCZ)99267000000027979020121116d2013 u| 0engur|n|---|||||txtccrSialo-Xenoantigenic Glycobiology Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation /by Kwon-Ho Song, Cheorl-Ho Kim1st ed. 2013.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2013.1 online resource (75 p.)Sungkyunkwan University Outstanding Research,2195-3554 ;1Description based upon print version of record.3-642-43443-6 3-642-34093-8 Includes bibliographical references.Screening of pig glycosyltransferase genes related to xenoantigens and their masking -- Cloning and tissue specific expression of pcmah and its alternative transcripts -- Functional characterization of pCMAH in the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-to-human xenotransplantation -- Identification of two alternative promoters of the pig CMP-N-acetylneuraminic acid hydroxylase gene -- Screening for xenoantigenic determinants formed by sialyltransferases.Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.  .Sungkyunkwan University Outstanding Research,2195-3554 ;1Biomedical engineeringMedicineResearchBiologyResearchMedical geneticsClinical biochemistryBiochemistryBiomedical Engineering and BioengineeringBiomedical ResearchMedical GeneticsMedical BiochemistryBiochemistryBiomedical engineering.MedicineResearch.BiologyResearch.Medical genetics.Clinical biochemistry.Biochemistry.Biomedical Engineering and Bioengineering.Biomedical Research.Medical Genetics.Medical Biochemistry.Biochemistry.572.567Song Kwon-ho1059100Kim Cheorl-ho1062709MiAaPQMiAaPQMiAaPQBOOK9910437894503321Sialo-xenoantigenic glycobiology4188344UNINA