03185nam 2200625Ia 450 991043785290332120251029141438.09783642259500364225950210.1007/978-3-642-25950-0(CKB)2670000000371088(EBL)1206018(SSID)ssj0000906497(PQKBManifestationID)11471220(PQKBTitleCode)TC0000906497(PQKBWorkID)10843426(PQKB)10277344(DE-He213)978-3-642-25950-0(MiAaPQ)EBC1206018(PPN)186030495(EXLCZ)99267000000037108820130325d2013 uy 0engur|n|---|||||txtccrCircadian clocks /Achim Kramer, Martha Merrow, editors1st ed. 2013.Hoboken, N.J. Springer20131 online resource (417 p.)Handbook of Experimental Pharmacology,0171-2004 ;217Description based upon print version of record.9783642448539 3642448534 9783642259494 3642259499 Includes biliographical references and index.Part I. Molecular and cellular basis of circadian clocks. Molecular components of the mammalian circadian clock. The epigenetic language of circadian clocks. Peripheral circadian oscillators in mammals. Cellular mechanisms of circadian pacemaking: beyond transcriptional loops. The clock in the brain: Neurons, glia and networks in daily rhythms -- Part II. Circadian control of physiology and behavior. Circadian clocks and metabolism. The circadian control of sleep. Daily regulation of hormone profiles. Circadian clocks and mood-related behaviors. Part III. Chronopharmacology and chronotherapy. Molecular Clocks in Pharmacology. Cancer chronotherapeutics: Experimental, theoretical and clinical aspects. Pharmacological modulators of the circadian clock as potential therapeutic drugs: Focus on genotoxic/anticancer therapy. Light and the human circadian clock -- Part IV. Systems biology of circadian clocks. Mathematical modeling in chronobiology. Mammalian circadian clock: the roles of transcriptional repression and delay. Genome-wide analyses of circadian systems. Proteomic approaches in circadian biology.This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.Handbook of Experimental Pharmacology,0171-2004 ;217Circadian rhythmsChronobiologyCircadian rhythms.Chronobiology.571.77Krämer Achim1939-1751932Merrow Martha1751933MiAaPQMiAaPQMiAaPQBOOK9910437852903321Circadian clocks4187074UNINA