05555nam 22008175 450 991043785170332120200630171552.03-642-38664-410.1007/978-3-642-38664-0(CKB)3710000000024377(EBL)1466334(OCoLC)862048913(SSID)ssj0001049041(PQKBManifestationID)11668848(PQKBTitleCode)TC0001049041(PQKBWorkID)11015080(PQKB)11601329(DE-He213)978-3-642-38664-0(MiAaPQ)EBC1466334(PPN)176112685(EXLCZ)99371000000002437720131004d2013 u| 0engur|n|---|||||txtccrPharmacotherapy of Pulmonary Hypertension /edited by Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch1st ed. 2013.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2013.1 online resource (569 p.)Handbook of Experimental Pharmacology,0171-2004 ;218Description based upon print version of record.3-642-38663-6 Includes bibliographical references and index.Preface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models -- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors -- Part III. Pulmonary hypertension: novel pathways and emerging therapies     Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy -- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions.This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.Handbook of Experimental Pharmacology,0171-2004 ;218PharmacologyPharmaceutical technologyInternal medicineRespiratory organs—DiseasesLaboratory medicineMolecular biologyPharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Pharmaceutical Sciences/Technologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21010Internal Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/H33002Pneumology/Respiratory Systemhttps://scigraph.springernature.com/ontologies/product-market-codes/H33134Laboratory Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B15007Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XPharmacology.Pharmaceutical technology.Internal medicine.Respiratory organs—Diseases.Laboratory medicine.Molecular biology.Pharmacology/Toxicology.Pharmaceutical Sciences/Technology.Internal Medicine.Pneumology/Respiratory System.Laboratory Medicine.Molecular Medicine.615.5/8618.922004636Humbert Marcedthttp://id.loc.gov/vocabulary/relators/edtEvgenov Oleg Vedthttp://id.loc.gov/vocabulary/relators/edtStasch Johannes-Peteredthttp://id.loc.gov/vocabulary/relators/edtBOOK9910437851703321Pharmacotherapy of pulmonary hypertension1078373UNINA