01349oam 2200409 450 991070802400332120180426124418.0(CKB)5470000002470273(OCoLC)1030746194(OCoLC)995470000002470273(EXLCZ)99547000000247027320180406d2014 ua 0engurmn|||||||||txtrdacontentcrdamediacrrdacarrierThe 3D Elevation Program summary for North Dakota /William J. Carswell, JrReston, VA :U.S. Department of the Interior, U.S. Geological Survey,2014.1 online resource (2 unnumbered pages) color illustrations, color mapFact sheet ;2014-3036"April 2014."Includes bibliographical references (page 2).3D Elevation Program Digital elevation modelsNorth DakotaThree-dimensional imagingNorth DakotaDigital elevation modelsThree-dimensional imagingCarswell William J.1387067Geological Survey (U.S.),GPOGPOGPOBOOK9910708024003321The 3D Elevation Program3436533UNINA03629nam 2200577Ia 450 991043785080332120200520144314.01-283-84894-51-4614-4666-X10.1007/978-1-4614-4666-8(CKB)2670000000279087(EBL)1030808(OCoLC)824487129(SSID)ssj0000789319(PQKBManifestationID)11413147(PQKBTitleCode)TC0000789319(PQKBWorkID)10726479(PQKB)10636383(DE-He213)978-1-4614-4666-8(MiAaPQ)EBC1030808(PPN)168300877(EXLCZ)99267000000027908720121211d2013 uy 0engur|n|---|||||txtccrAdvances in biology and therapy of multiple myelomaVolume 1Basic science /Nikhil C. Munshi, Kenneth C. Anderson, editorsNew York Springerc20131 online resource (321 p.)Description based upon print version of record.1-4614-4665-1 Includes bibliographical references and index.Genomic strategies determining progressions from MGUS to Multiple Myeloma -- Prognostic implication of Genetic changes (Cytogenetics, and FISH, gains and losses of DNA by SNP array and aCGH) in risk stratification in myeloma -- Advances in MM gene expression profiling -- Growth factors in MM -- Role of Wnt signaling pathways in multiple myeloma pathogenesis -- mTOR pathway in multiple myeloma -- Jak/STAT signaling in the pathogenesis and treatment of multiple myeloma -- Role of extracellular matrix in myeloma biology -- Osteoclasts: Potential target for blocking microenvironmental support of myeloma -- Targeting the BAFF/APRIL cytokine network in multiple myeloma -- Role of Osteoblast in myeloma pathology -- Migration and homing in Multiple Myeloma -- Genes and proteins of myeloma endothelial cells to search specific targets of the tumor vasculature -- Epigenetic regulation of myeloma within its bone marrow microenvironment -- Targeting mulitple myeloma tumor angiogenesis: focus on VEGF -- Novel in vivo model in myeloma -- Index.Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.   This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.Bone marrowDiseasesMyelodysplastic syndromesBone marrowDiseases.Myelodysplastic syndromes.616.99/418616.9941806Munshi Nikhil C1064467Anderson Kenneth C876632MiAaPQMiAaPQMiAaPQBOOK9910437850803321Advances in biology and therapy of multiple myeloma2538380UNINA