03664nam 2200577Ia 450 991043784930332120200520144314.01-299-40862-194-007-5842-110.1007/978-94-007-5842-1(CKB)2670000000338260(EBL)1083662(OCoLC)828302725(SSID)ssj0000870680(PQKBManifestationID)11474727(PQKBTitleCode)TC0000870680(PQKBWorkID)10818743(PQKB)10841237(DE-He213)978-94-007-5842-1(MiAaPQ)EBC1083662(PPN)168341905(EXLCZ)99267000000033826020121219h20132013 uy 0engur|n|---|||||txtccrCancer genomics molecular classification, prognosis and response prediction /Ulrich Pfeffer, editor1st ed. 2013.Dordrecht Springerc20131 online resource (590 p.)Description based upon print version of record.94-007-9802-4 94-007-5841-3 Includes bibliographical references and index.Preface -- Genomic Pathology of Lung Cancer -- Understanding Melanoma Progression by Gene Expression Signatures -- Prognostic testing in uveal melanoma -- Capturing and Deciphering the Molecular Signatures of Head and Neck Cancer -- Predictive and Prognostic Biomarkers for Colorectal Cancer -- Expression Profiling of Hepatocellular Carcinoma -- Kidney Cancer Genomics: Paving the Road to a New Paradigm of Personalized Medicine -- 8 Pancreatic cancer genomics -- Breast Cancer Genomics: From Portraits to Landscapes -- Genomic landscape of ovarian cancer -- Genetics of Endometrial Carcinoma -- Usefulness of molecular biology in follicular-derived thyroid tumors - From translationnal research to clinical practice -- Sarcomas Genetics: From point mutation to complex karyotype, from diagnosis to therapies -- Novel molecular acquisitions in leukemias -- Where do we stand in the genomics of lymphomas?- The Genomics of Multiple Myeloma and Its Relevance in the Molecular Classification and Risk Stratification of the Disease -- Index.The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with  its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first  ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident. .CancerGenetic aspectsGenomicsCancerGenetic aspects.Genomics.616.994042Pfeffer Ulrich798794MiAaPQMiAaPQMiAaPQBOOK9910437849303321Cancer genomics4186542UNINA