04107nam 22006495 450 991043784080332120200703081219.01-4614-8289-510.1007/978-1-4614-8289-5(CKB)3710000000024288(EBL)1538805(SSID)ssj0001049015(PQKBManifestationID)11609376(PQKBTitleCode)TC0001049015(PQKBWorkID)11017955(PQKB)10627024(DE-He213)978-1-4614-8289-5(MiAaPQ)EBC1538805(iGPub)SPNA0026891(PPN)176098569(EXLCZ)99371000000002428820131008d2013 u| 0engur|n|---|||||txtccrGadd45 Stress Sensor Genes /edited by Dan A. Liebermann, Barbara Hoffman1st ed. 2013.New York, NY :Springer New York :Imprint: Springer,2013.1 online resource (141 p.)Advances in Experimental Medicine and Biology,0065-2598 ;793Description based upon print version of record.1-4614-8288-7 Includes bibliographical references and index.Gadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver — Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia -- Index.Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  .Advances in Experimental Medicine and Biology,0065-2598 ;793Medical geneticsBiochemistryHuman geneticsGene Functionhttps://scigraph.springernature.com/ontologies/product-market-codes/B12030Biochemistry, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/L14005Human Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Medical genetics.Biochemistry.Human genetics.Gene Function.Biochemistry, general.Human Genetics.572Liebermann Dan Aedthttp://id.loc.gov/vocabulary/relators/edtHoffman Barbaraedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910437840803321Gadd45 Stress Sensor Genes2510105UNINA