03419nam 2200601 a 450 991043783540332120200520144314.01-283-93490-63-642-27928-710.1007/978-3-642-27928-7(CKB)2670000000317328(EBL)1082435(OCoLC)823388540(SSID)ssj0000864732(PQKBManifestationID)11942009(PQKBTitleCode)TC0000864732(PQKBWorkID)10837288(PQKB)10327395(DE-He213)978-3-642-27928-7(MiAaPQ)EBC1082435(PPN)168311208(EXLCZ)99267000000031732820121107d2013 uy 0engur|n|---|||||txtccrProtein quality control in neurodegenerative diseases /Richard I. Morimoto, Yves Christen, editors1st ed. 2013.New York Springer20131 online resource (144 p.)Research and perspectives in Alzheimer's disease,0945-6066Description based upon print version of record.3-642-44706-6 3-642-27927-9 Includes bibliographical references and index.The Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto -- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron -- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin -- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen -- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo -- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima -- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl -- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner -- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri -- Subject code.The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.Research and Perspectives in Alzheimer's Disease,0945-6066Nervous systemDegenerationNervous systemDegeneration.616.8616.80471Morimoto Richard I1760051Christen Yves155886MiAaPQMiAaPQMiAaPQBOOK9910437835403321Protein quality control in neurodegenerative diseases4198831UNINA