04034nam 22006855 450 991043783540332120200704190837.01-283-93490-63-642-27928-710.1007/978-3-642-27928-7(CKB)2670000000317328(EBL)1082435(OCoLC)823388540(SSID)ssj0000864732(PQKBManifestationID)11942009(PQKBTitleCode)TC0000864732(PQKBWorkID)10837288(PQKB)10327395(DE-He213)978-3-642-27928-7(MiAaPQ)EBC1082435(PPN)168311208(EXLCZ)99267000000031732820121212d2013 u| 0engur|n|---|||||txtccrProtein Quality Control in Neurodegenerative Diseases[electronic resource] /edited by Richard I. Morimoto, Yves Christen1st ed. 2013.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2013.1 online resource (144 p.)Research and Perspectives in Alzheimer's Disease,0945-6066Description based upon print version of record.3-642-44706-6 3-642-27927-9 Includes bibliographical references and index.The Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto -- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron -- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin -- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen -- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo -- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima -- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl -- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner -- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri -- Subject code.The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.Research and Perspectives in Alzheimer's Disease,0945-6066NeurosciencesNeurochemistryMolecular biologyNeuroscienceshttps://scigraph.springernature.com/ontologies/product-market-codes/B18006Neurochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/B18010Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XNeurosciences.Neurochemistry.Molecular biology.Neurosciences.Neurochemistry.Molecular Medicine.616.8616.80471Morimoto Richard Iedthttp://id.loc.gov/vocabulary/relators/edtChristen Yvesedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910437835403321Protein Quality Control in Neurodegenerative Diseases2513712UNINA