04006nam 22006375 450 991043782710332120200707004530.01-283-62448-697866139369361-4614-4815-810.1007/978-1-4614-4815-0(CKB)2670000000246545(EBL)994590(OCoLC)811139863(SSID)ssj0000767095(PQKBManifestationID)11429475(PQKBTitleCode)TC0000767095(PQKBWorkID)10739886(PQKB)11209362(DE-He213)978-1-4614-4815-0(MiAaPQ)EBC994590(PPN)16830127X(EXLCZ)99267000000024654520120913d2013 u| 0engur|n|---|||||txtccrMicrodialysis in Drug Development[electronic resource] /edited by Markus Müller1st ed. 2013.New York, NY :Springer New York :Imprint: Springer,2013.1 online resource (341 p.)AAPS Advances in the Pharmaceutical Sciences Series,2210-7371 ;4Description based upon print version of record.1-4899-9621-4 1-4614-4814-X Includes bibliographical references and index.Introduction to the Microdialysis Technology -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis -- Analytical Considerations for Microdialysis Sampling -- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations -- Microdialysis in Antibiotic Research -- Skin and Transdermal Drug Delivery: Advantages and Challenges -- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis -- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease -- Microdialysis in Pain Research -- Microdialysis in Ocular Drug Development -- Microdialysis in Metabolic Research -- High Molecular Weight Targets and Treatments Using Microdialysis -- Complementary Techniques – Positron Emission Tomography -- Open Flow Microperfusion: An Alternative Method to Microdialysis? -- Microdialysis in Internal Organs and Tumors.In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.AAPS Advances in the Pharmaceutical Sciences Series,2210-7371 ;4Pharmaceutical technologyMedicinePharmaceutical Sciences/Technologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21010Biomedicine, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/B0000XPharmaceutical technology.Medicine.Pharmaceutical Sciences/Technology.Biomedicine, general.615/.19616.8/04754Müller Markusedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910437827103321Microdialysis in Drug Development2530770UNINA