02938nam 2200661Ia 450 991043779810332120200520144314.01-283-63167-997866139441223-642-32051-110.1007/978-3-642-32051-4(CKB)2670000000250604(EBL)1030350(OCoLC)809794112(SSID)ssj0000738579(PQKBManifestationID)11378515(PQKBTitleCode)TC0000738579(PQKBWorkID)10792158(PQKB)11132897(DE-He213)978-3-642-32051-4(MiAaPQ)EBC1030350(PPN)168320908(EXLCZ)99267000000025060420120922h20122013 uy 0engur|n|---|||||txtccrNovel synthetic chemistry of ureas and amides doctoral thesis accepted by the University of Bristol, UK /Marc Hutchby1st ed. 2013.Heidelberg Springer2012, c20131 online resource (178 p.)Springer theses : recognizing outstanding Ph.D. research,2190-5053Description based upon print version of record.3-642-44890-9 3-642-32050-3 Includes bibliographical references.Transition metal catalysis -- Palladium catalysis -- Pd(II) catalysed aminocarbonylation of alkenes -- Carbonylation of aryl ureas -- Urea Hydrolysis -- Amide hydrolysis.In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.Springer theses.Organic compoundsSynthesisChemical bondsUreaAmidesOrganic compoundsSynthesis.Chemical bonds.Urea.Amides.660.6Hutchby Marc1059105MiAaPQMiAaPQMiAaPQBOOK9910437798103321Novel Synthetic Chemistry of Ureas and Amides2504168UNINA