02803oam 2200517 450 991043779800332120190911112726.03-642-40717-X10.1007/978-3-642-40717-8(OCoLC)870684408(MiFhGG)GVRL6VAI(EXLCZ)99371000000007885020131023d2013 uy 0engurun|---uuuuatxtccrHemoglobin-based oxygen carriers as red cell substitutes and oxygen therapeutics /Hae Won Kim, A. Gerson Greenburg, editors1st ed. 2013.Heidelberg [Germany] :Springer,2013.1 online resource (xxiii, 746 pages) illustrations (some color)Gale eBooksDescription based upon print version of record.3-642-40716-1 Includes bibliographical references at the end of each chapters.Brief historical account of HBOC development -- Physiology of respiration -- Oxygen transport to tissues -- Pathophysiology of acute anemia -- Global blood safety and need for safe blood supply -- Blood transfusion and its limitations -- Scientific basis and design of HBOCs -- HBOCs: a regulatory perspective -- Current HBOC products in development -- Clinical indications and clinical trials of HBOCs -- HBOCs and adverse events observed in clinical trials -- HBOC-mediated vasoactivity and hypertension -- HBOC and oxygen and nitrogen radical mediated toxicity -- HBOCs and clinical laboratory interference -- Animal models for HBOC studies -- New emerging Technologies for universal RBCs -- Future prospects.Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.OxygenPhysiological transportOxygen therapyBlood substitutesOxygenPhysiological transport.Oxygen therapy.Blood substitutes.611.01816615.19615.399616.15Kim Hae WonGreenburg A. GersonMiFhGGMiFhGGBOOK9910437798003321Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics2538306UNINA