03576nam 2200589 a 450 991043779670332120200520144314.094-007-5285-710.1007/978-94-007-5285-6(CKB)2670000000280493(EBL)1030738(OCoLC)819631493(SSID)ssj0000798779(PQKBManifestationID)11501268(PQKBTitleCode)TC0000798779(PQKBWorkID)10743606(PQKB)11273872(DE-He213)978-94-007-5285-6(MiAaPQ)EBC1030738(PPN)168340461(EXLCZ)99267000000028049320121009d2013 uy 0engur|n|---|||||txtccrIdentification of ligand binding site and protein-protein interaction area /Irena Roterman-Konieczna, editor1st ed. 2013.Dordrecht Springer20131 online resource (172 p.)Focus on structural biology,1571-4853 ;v. 8Description based upon print version of record.94-017-8284-9 94-007-5284-9 Includes bibliographical references and index.Contributors -- Foreword -- Chapter 1 SuMo, J-A. Chemelle, E. Bettler, CH. Combet, R. Terreux, CH. Geourjon, G. Deleage -- Chapter 2 Identification of pockets on protein surface to predict protein–ligand binding sites, Binding Huang -- Chapter 3 Can the structure of the hydrophobic core determine the complexation site?, M. Banach, L. Konieczny, I. Roterman -- Chapter 4 Comparative analysis of techniques oriented on the recognition of ligand binding area in proteins, P. Alejster, M. Banach, W. Jurkowski, D. Marchewka, I. Roterman -- Chapter 5 Docking predictions of protein-protein interactions and their assessment, Joel Janin -- Chapter 6 Prediction of protein-protein binding interfaces, D. Marchewka, W. Jurkowski, M. Banach, I. Roterman -- Chapter 7 Support for Cooperative Experiments in e-Science: From Scientific Workflows to Knowledge Sharing, A. Belloum, R. Cushing, S. Koulouzis, V. Korkhov, D. Vasunin, V. Guevara-Masis, Z. Zhao, M. Bubak -- Index.This volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected. Developing such tools is not an easy task – it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research.Focus on Structural Biology,1571-4853 ;8Ligand binding (Biochemistry)Protein bindingLigand binding (Biochemistry)Protein binding.572.33Roterman-Konieczna Irena1133571MiAaPQMiAaPQMiAaPQBOOK9910437796703321Identification of ligand binding site and protein-protein interaction area4184777UNINA