03225nam 2200709 a 450 991043762360332120200520144314.03-0348-0688-410.1007/978-3-0348-0688-6(CKB)2670000000533705(EBL)1398546(OCoLC)858763846(SSID)ssj0000986606(PQKBManifestationID)11544770(PQKBTitleCode)TC0000986606(PQKBWorkID)10938782(PQKB)10960147(DE-He213)978-3-0348-0688-6(MiAaPQ)EBC1398546(PPN)172421942(EXLCZ)99267000000053370520130604d2013 uy 0engur|n|---|||||txtccrGenomics of pattern recognition receptors applications in oncology and cardiovascular diseases /Anton G. Kutikhin, Arseniy E. Yuzhalin1st ed. 2013.New York Springer20131 online resource (190 p.)Description based upon print version of record.3-0348-0687-6 3-0348-0794-5 Includes bibliographical references.The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go.This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.Cell receptorsGeneticsReceptorsImmunologyCancerResearchHuman geneticsCell receptors.Genetics.Receptors.Immunology.CancerResearch.Human genetics.570572696574.87599935Kutikhin Anton G1059920Yuzhalin Arseniy E1751477MiAaPQMiAaPQMiAaPQBOOK9910437623603321Genomics of pattern recognition receptors4186464UNINA