03010nam 2200577Ia 450 991043762180332120200520144314.01-4614-4660-01-299-19720-510.1007/978-1-4614-4660-6(CKB)2670000000529989(EBL)1081850(OCoLC)826853733(SSID)ssj0000878962(PQKBManifestationID)11560822(PQKBTitleCode)TC0000878962(PQKBWorkID)10850323(PQKB)11009698(DE-He213)978-1-4614-4660-6(MiAaPQ)EBC1081850(PPN)168300850(EXLCZ)99267000000052998920130116d2013 uy 0engur|n|---|||||txtccrGenetic and molecular epidemiology of multiple myeloma /Suzanne Lentzsch, editor1st ed. 2013.New York, NY Springerc20131 online resource (130 p.)Description based upon print version of record.1-4614-4659-7 1-4899-9865-9 Includes bibliographical references and index.Preface -- Genetics of Multiple Myeloma -- Gene expression signature in MGUS and multiple myeloma -- Cap-Dependent Protein Translation Initiation in Multiple Myeloma: an Attractive Target for Therapy -- IRES-dependent, CAP-independent translation in Multiple Myeloma -- Epigenetic gene silencing as a new target for multiple myeloma -- Role of Bone Disease in the Pathogenesis of Multiple Myeloma -- Index.This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.  Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.Multiple myelomaEpidemiologyB cellsTumorsMultiple myelomaEpidemiology.B cellsTumors.616.99418Lentzsch Suzanne1755170MiAaPQMiAaPQMiAaPQBOOK9910437621803321Genetic and molecular epidemiology of multiple myeloma4191859UNINA