03086nam 2200541Ia 450 991043762090332120200520144314.094-007-4667-910.1007/978-94-007-4667-1(CKB)2550000001047287(EBL)1206400(SSID)ssj0000880099(PQKBManifestationID)11524670(PQKBTitleCode)TC0000880099(PQKBWorkID)10873235(PQKB)11452900(DE-He213)978-94-007-4667-1(MiAaPQ)EBC1206400(PPN)169141764(EXLCZ)99255000000104728720130129d2013 uy 0engur|n|---|||||txtccrThe chaperonopathies diseases with defective molecular chaperones /Alberto J.L. Macario, Everly Conway de Macario, Francesco Cappello1st ed. 2013.New York Springer20131 online resource (116 p.)SpringerBriefs in Biochemistry and Molecular Biology,2211-9353Description based upon print version of record.94-007-4666-0 Overview and book plan -- Chaperones: General characteristics and classifications -- The chaperonopathies: classification, mechanisms, structural features -- Structural and hereditary chaperonopathies: mutation -- Other genetic chaperonopathies -- Acquired chaperonopathies -- Other types of chaperonopathies -- Impact of chaperonopathies in protein homeostasis and beyond -- Extracellular chaperones.Memory lapses and occasional incoherent behavior, or intestinal cramps with diarrhea, or protracted cough with low fever, or cardiovascular syndromes, or changes in the pattern of movement of the lower limps, can be signs of an incipient chaperonopathy. Yet many physicians do not know this. Most health care professionals are unfamiliar with chaperonopathies. Clinicians do not look for them because they are unaware of them. Pathologists and clinical biochemists are unprepared to test specimens to detect chaperonopathies. Despite the large amount of information available in the literature, textbooks tend to ignore chaperonopathies. Because of the lack of systematic information in textbooks and courses, chaperonopathies are invisible to practitioners and clinical researchers. This book aims to correct this situation by providing pertinent information in an orderly manner so as to prompt the reader to look for chaperonopathies in patients and seek more information about them. The book serves as an alert signal and as a primer.SpringerBriefs in Biochemistry and Molecular Biology,2211-9353Molecular chaperonesDiseasesMolecularMolecular chaperones.DiseasesMolecular.572.633MiAaPQMiAaPQMiAaPQBOOK9910437620903321The Chaperonopathies2513103UNINA