03005nam 2200577Ia 450 991043762010332120200520144314.03-0348-0682-510.1007/978-3-0348-0682-4(CKB)2670000000406494(EBL)1398545(SSID)ssj0000958047(PQKBManifestationID)11485122(PQKBTitleCode)TC0000958047(PQKBWorkID)10986689(PQKB)11749943(DE-He213)978-3-0348-0682-4(MiAaPQ)EBC1398545(PPN)172421934(EXLCZ)99267000000040649420130731d2013 uy 0engur|n|---|||||txtccrGamma-glutamyl transpeptidases structure and function /by Immacolata Castellano, Antonello Merlino1st ed. 2013.Basel Springer20131 online resource (65 p.)SpringerBriefs in biochemistry and molecular biologyDescription based upon print version of record.3-0348-0681-7 Includes bibliographical references. 1 Introduction -- 2 Occurrence, genes and gene expression -- 3 Structure and function of γ-GTs -- 4 Autoprocessing and reaction mechanism of γ-GTs -- 5 γ-GT in bioclinical -- 6 γ-GTs: biotechnological and biomedical applications -- 7 Conclusions -- References. Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.SpringerBriefs in Biochemistry and Molecular Biology,2211-9353PeptidaseTranspeptidationPeptidase.Transpeptidation.612.0151Castellano Immacolata1060386Merlino Antonello1762279MiAaPQMiAaPQMiAaPQBOOK9910437620103321Gamma-glutamyl transpeptidases4202092UNINA