03717nam 2200637 a 450 991043761950332120200520144314.03-0348-0664-710.1007/978-3-0348-0664-0(CKB)2670000000406493(EBL)1398543(SSID)ssj0000958079(PQKBManifestationID)11485126(PQKBTitleCode)TC0000958079(PQKBWorkID)10986112(PQKB)10336833(DE-He213)978-3-0348-0664-0(MiAaPQ)EBC1398543(PPN)172421926(EXLCZ)99267000000040649320130529d2013 uy 0engur|n|---|||||txtccrTamoxifen pioneering medicine in breast cancer /Philipp Y. Maximov, Russell E. McDaniel, V. Craig Jordan1st ed. 2013.Basel Springer20131 online resource (218 p.)Milestones in drug therapyDescription based upon print version of record.3-0348-0783-X 3-0348-0663-9 Includes bibliographical references.Discovery and Pharmacology of Nonsteroidal Estrogens and Antiestrogens -- Tamoxifen Goes Forward Alone -- Metabolites of Tamoxifen as the Basis of Drug Development -- Adjuvant Therapy – The Breakthrough -- The Wisconsin Story in the 1980’s: Discovery of Target Site Specific Estrogen Action -- Carcinogenesis and Tamoxifen -- Chemoprevention: Cinderella waiting for the ball -- Tamoxifen and Raloxifene head to head: The STAR TRIAL -- Acquired resistance to Tamoxifen: back to the beginning -- The legacy of Tamoxifen -- Appendix: Four decades of discovery in breast cancer research and treatment – an interview with V. Craig Jordan by Marc Poirot -- Selected Awards that Recognize the Contribution of Tamoxifen and Raloxifene to Medicine.Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the “father of tamoxifen” - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a “failed morning after contraceptive” to become the “gold standard” for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen’s pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.Milestones in Drug Therapy,2296-6056TamoxifenBreastCancerChemopreventionBreastCancerChemotherapyTamoxifen.BreastCancerChemoprevention.BreastCancerChemotherapy.616.99449061616.99449061Maximov Philipp Y1065515Jordan V. Craig(Virgil Craig)1759158McDaniel Russell E1759159MiAaPQMiAaPQMiAaPQBOOK9910437619503321Tamoxifen4197526UNINA