04492nam 22006615 450 991043761560332120200704072958.01-4614-7969-X10.1007/978-1-4614-7969-7(CKB)2670000000530517(EBL)1398496(OCoLC)858763758(SSID)ssj0000986623(PQKBManifestationID)11942278(PQKBTitleCode)TC0000986623(PQKBWorkID)10938068(PQKB)11602195(DE-He213)978-1-4614-7969-7(MiAaPQ)EBC1398496(PPN)172420342(EXLCZ)99267000000053051720130813d2013 u| 0engur|n|---|||||txtccrStearoyl-CoA Desaturase Genes in Lipid Metabolism[electronic resource] /edited by James M. Ntambi, Ph.D1st ed. 2013.New York, NY :Springer New York :Imprint: Springer,2013.1 online resource (241 p.)Description based upon print version of record.1-4614-7968-1 1-4939-0153-2 Includes bibliographical references and index.SCD genes of fatty acid synthesis -- SCD genes in heart metabolism -- SCD genes in liver metabolism -- SCD genes in harderian and perpetual glands -- SCD genes In lipogenesis -- SCD genes lipoproteins -- SCD genes in WAT -- SCD genes in muscle -- SCD genes in the brain -- SCD genes in inflammation -- SCD genes in ER Stress -- SCD genes in skin -- SCD genes in insulin signaling -- SCD genes in thermogenesis -- SCD genes in diabetes -- SCD genes atherosclerosis -- SCD genes in Adipocyte differentiation -- SCD genes and epigenetics -- SCD genes in fatty liver disease -- SCD genes in Colitis -- SCD genes in leptin signaling.James Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids. A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date.Human geneticsEndocrinology LipidsHuman Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Endocrinologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33053Lipidologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L14080Human genetics.Endocrinology .Lipids.Human Genetics.Endocrinology.Lipidology.572.57599935610611.01816Ntambi Ph.D., James Medthttp://id.loc.gov/vocabulary/relators/edtBOOK9910437615603321Stearoyl-CoA Desaturase Genes in Lipid Metabolism2513096UNINA