01986nam 2200361z- 450 99104277317033212021021182-15-04119-1(CKB)4100000011665494(oapen)https://directory.doabooks.org/handle/20.500.12854/40384(oapen)doab40384(EXLCZ)99410000001166549420202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdvancing Systems Epidemiology in Cancer - Exploring Trajectories of Gene ExpressionScandinavian University Press (Universitetsforlaget)20201 online resource (187 p.)82-15-04120-5 This book introduces systems epidemiology, which is a new scientific discipline borne by novel technologies. These have opened up the potential for studies of temporal changes in the carcinogenic process and the response of the immune system, all measured as functional genomics: gene expression, microRNA and methylation. Systems epidemiology is an integrated approach based on epidemiological methods with biobanks designed for studies of the trajectories or curves of functional genomics moving from before diagnosis, at diagnosis and postdiagnostic. It demands new epidemiological designs, the globolomic one, new statistical methods for description and analyses of time changes and incorporating basic knowledge from reductionist experiments and clinical outcomes including molecular biomarkers of cancer tissue and normal tissues.Advancing Systems Epidemiology in CancerMedicinebicsscCancerepidemiologyMedicineEiliv Lundauth1291000BOOK9910427731703321Advancing Systems Epidemiology in Cancer - Exploring Trajectories of Gene Expression3021739UNINA