02548nam 2200505 450 991042463750332120210327175554.0981-15-8807-410.1007/978-981-15-8807-5(CKB)4100000011528337(MiAaPQ)EBC6380987(DE-He213)978-981-15-8807-5(PPN)260301736(EXLCZ)99410000001152833720210327d2020 uy 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierCircadian pharmacokinetics /edited by Baojian Wu, Danyi Lu, Dong Dong1st ed. 2020.Singapore :Springer,[2020]©20201 online resource (VII, 253 p. 59 illus., 46 illus. in color.) 981-15-8806-6 Chapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.PharmacologyPharmacyMedicinePharmacology.Pharmacy.Medicine.780Wu BaojianLu DanyiDong DongMiAaPQMiAaPQMiAaPQBOOK9910424637503321Circadian pharmacokinetics2495865UNINA