04281oam 2200805 450 991041835470332120230621135401.03-030-41480-910.1007/978-3-030-41480-1(CKB)4100000011392509(DE-He213)978-3-030-41480-1(MiAaPQ)EBC6310312(Au-PeEL)EBL6310312(OCoLC)1243532476(oapen)https://directory.doabooks.org/handle/20.500.12854/35896(EXLCZ)99410000001139250920200818h20212021 fy 0engurmn#---|||||txtrdacontentcrdamediacrrdacarrierHuman challenge studies in endemic settings ethical and regulatory issues /Euzebiusz Jamrozik, Michael J. SelgelidSpringer Nature2021Cham, Switzerland :Springer Nature Switzerland AG :Imprint: SpringerOpen,[2021]©20211 online resource (xvii, 134 pages) illustrations; PDF, digital file(s)SpringerBriefs in Ethics,2211-8101Print version: 9783030414795 Includes bibliographical references.1. Introduction -- 2. Methods -- 3. History of human challenge studies -- 4. ethical issues -- 5. Community engagement, ethics review, and regulation -- 6. Case studies -- 7. Conclusions -- Acknowledgements. .This open access book provides an extensive review of ethical and regulatory issues related to human infection challenge studies, with a particular focus on the expansion of this type of research into endemic settings and/or low- and middle-income countries (LMICs). Human challenge studies (HCS) involve the intentional infection of research participants, and this type of research is rapidly increasing in frequency worldwide. HCS are widely considered to be an especially promising approach to vaccine development, including for pathogens endemic to LMICs. However, challenge studies are sometimes controversial and raise complex ethical issues, some of which are especially salient in endemic and/or LMIC settings. Informed by qualitative interviews with experts in infectious diseases and bioethics, this book highlights areas of ethical consensus and controversy concerning this kind of research. As the first volume to focus on ethical issues associated with human challenge studies, it sets the agenda for further work in this important area of global health research; contributes to current debates in research ethics; and aims to inform regulatory policy and research practice. Insofar as it focuses on HCS in (endemic) settings where diseases are present and/or widespread, much of the analysis provided here is directly relevant to HCS involving pandemic diseases including COVID19.SpringerBriefs in Ethics,2211-8101.BioethicsInfectious diseasesVaccinesEconomic developmentBioethicsInfectious DiseasesVaccineDevelopment and HealthMoral Philosophy and Applied EthicsInternal MedicinePharmacologyDevelopment Studieshuman challenge studiesOpen Accesscapacity building in low-income countriescapacity building in middle-income countriesmalariotherapyintentional infectionethics of challenge studieschallenge studies in endemic settingschallenge studies and vulnerable populationsFalciparum malaria challenge studies in AfricaInfectious & contagious diseasesImmunologyDevelopment studiesBioethics.Infectious diseases.Vaccines.Economic development.171.7Jamrozik Euzebiusz899608Selgelid Michael J.UkMaJRUBOOK9910418354703321Human challenge studies in endemic settings2010023UNINA