03323nam 22006015 450 991041610920332120220422103607.03-319-68864-210.1007/978-3-319-68864-0(CKB)4100000011343349(DE-He213)978-3-319-68864-0(MiAaPQ)EBC6264031(EXLCZ)99410000001134334920200713d2020 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierDrug Discovery and Evaluation: Methods in Clinical Pharmacology /edited by Franz J. Hock, Michael R. Gralinski2nd ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (249 illus., 179 illus. in color. eReference.)Springer referenceIncludes index.3-319-68863-4 This is the second edition of a well-received book in the series “Drug Discovery and Evaluation” The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology". For the 2nd edition of this volume, the chapters have been revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases.Springer reference.PharmacologyMedical biochemistryPharmacotherapyPharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Medical Biochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/H35005Pharmacotherapyhttps://scigraph.springernature.com/ontologies/product-market-codes/H69000FarmacologiathubLlibres electrònicsthubPharmacology.Medical biochemistry.Pharmacotherapy.Pharmacology/Toxicology.Medical Biochemistry.Pharmacotherapy.Farmacologia615.19Hock Franz Jedthttp://id.loc.gov/vocabulary/relators/edtGralinski Michael Redthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910416109203321Drug Discovery and Evaluation: Methods in Clinical Pharmacology2513355UNINA