03980nam 2200637 450 991081388530332120230725022856.00-19-939746-5(CKB)2560000000296742(EBL)3056050(OCoLC)755734873(SSID)ssj0000508626(PQKBManifestationID)11313565(PQKBTitleCode)TC0000508626(PQKBWorkID)10555117(PQKB)11561123(StDuBDS)EDZ0000038714(MiAaPQ)EBC3056050(Au-PeEL)EBL3056050(CaPaEBR)ebr10837072(CaONFJC)MIL573871(EXLCZ)99256000000029674220100317d2011 uy| 0engur|n|---|||||txtccrThe dynamic brain an exploration of neuronal variability and its functional significance /edited by Mingzhou Ding, Dennis L. GlanzmanNew York :Oxford University Press,2011.1 online resource (393 p.)Description based upon print version of record.0-19-539379-1 0-19-989704-2 Includes bibliographical references and index.A mixed-filter algorithm for dynamically tracking learning from multiple behavioral and neurophysiological measures / Todd P. Coleman ... [et al.] -- Stochastic transitions between states of neural activity / Paul Miller and Donald B. Katz -- Neural coding : variability and information / Richard B. Stein and Dirk G. Everaert -- Interactions between intrinsic and stimulus-evoked activity in recurrent neural networks / Larry F. Abbott, Kanaka Rajan, and Haim Sompolinsky -- Inherent biases in spontaneous cortical dynamics / Chou P. Hung, Benjamin M. Ramsden, and Anna Wang Roe -- Phase resetting in the presence of noise and heterogeneity / Srisairam Achuthan ... [et al.] -- Understanding animal-to-animal variability in neuronal and network properties / Astrid A. Prinz, Tomasz G. Smolinski, and Amber E. Hudson -- Dynamical parameter and state estimation in neuron models / Henry D.I. Abarbanel ... [et al.] --Capturing "trial-to-trial" variations in human brain activity : from laboratory to real world / Akaysha C. Tang, Matthew T. Sutherland, and Zhen Yang -- Linking neuronal variability to perceptual decision making via neuroimaging / Paul Sajda ... [et al.] -- Spatiotemporal dynamics of synchronous activity across multiple areas of the visual cortex in the alert monkey / Charles M. Gray and Baldwin Goodell -- Behavioral and neural variability related to stochastic choices during a mixed-strategy game / Daeyeol Lee and Hyojung Seo -- Circuit mechanisms underlying behavioral variability during recovery of consciousness following severe brain injury / Nicholas D. Schiff -- Intermittent vorticity, power spectral scaling, and dynamical measures on resting brain magnetic field fluctuations : a pilot study / Arnold J. Mandell ... [et al.] -- Population variability and Bayesian inference / Terran Lane.It is a well-known fact of neurophysiology that neuronal responses to identically presented stimuli are extremely variable. This book examines neuronal variability from theoretical, experimental and clinical perspectives.Neural circuitryNeural networks (Neurobiology)Evoked potentials (Electrophysiology)Variability (Psychometrics)Neural circuitry.Neural networks (Neurobiology)Evoked potentials (Electrophysiology)Variability (Psychometrics)612.8/2Ding Mingzhou67818Glanzman Dennis1677355MiAaPQMiAaPQMiAaPQBOOK9910813885303321The dynamic brain4044176UNINA03545nam 22005055 450 991041610770332120250610110203.03-030-48283-910.1007/978-3-030-48283-1(CKB)4100000011343506(DE-He213)978-3-030-48283-1(MiAaPQ)EBC6273633(PPN)260302473(MiAaPQ)EBC6264054(MiAaPQ)EBC29090359(EXLCZ)99410000001134350620200714d2020 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierNext Generation Kinase Inhibitors Moving Beyond the ATP Binding/Catalytic Sites /edited by Paul Shapiro1st ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (XII, 217 p. 59 illus., 56 illus. in color.)3-030-48282-0 Chapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors -- Chapter 2: Overview of Current Type I/II Kinase Inhibitors -- Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors -- Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins -- Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches -- Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition -- Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases -- Chapter 8: Novel peptide-based inhibitors of protein kinases -- Index.Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease. .CancerResearchCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Proteïnes quinasesthubLlibres electrònicsthubCancerResearch.Cancer Research.Proteïnes quinases.572.792Shapiro Pauledthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910416107703321Next Generation Kinase Inhibitors2147580UNINA