03544oam 2200649I 450 991041165240332120240424225739.0978100021894710002189459780429146060042914606X978143982492414398249249781439824931143982493210.1201/b13591 (CKB)2670000000593707(Au-PeEL)EBL4742762(CaPaEBR)ebr11317456(OCoLC)967107295(OCoLC)901280683(MiAaPQ)EBC4742762(FINmELB)ELB142821(ScCtBLL)36cc0ff5-c39b-4072-9ae3-c3cf447d73ff(EXLCZ)99267000000059370720180706d2010 uy 0engurcnu||||||||rdacontentrdamediardacarrierThe cost manual of laboratory animal care and use refinement, reduction, and research /edited by Bryan Howard, Timo Nevalainen and Gemma PerrettaFirst edition.Boca Raton, FL :CRC Press, an imprint of Taylor and Francis,2010.1 online resource (424 pages)9781322612515 132261251X 9781466547810 1466547812 Includes bibliographical references at the end of each chapters.chapter 1 Introduction -- chapter 2 Design and Oversight of Laboratory Animal Facilities -- chapter 3 Housing and Care of Laboratory Animals -- chapter 4 Animal Needs and Environmental Refinement -- chapter 5 Ethical Evaluation of ScientificProcedures: Recommendations for Ethics Committees -- chapter 6 Reduction by Careful Design and Statistical Analysis -- chapter 7 Animal Models: Selecting and Preparing Animals for a Study -- chapter 8 Creation of Genetically Modified Animals -- chapter 9 Management of Genetically Modified Rodents -- chapter 10 Impact of Handling,Radiotelemetry, and Food Restriction -- chapter 11 Basic Procedures: Dosing,Sampling and Immunisation -- chapter 12 Imaging Techniques -- chapter 13 Anaesthesia and Analgesia -- chapter 14 Use of Humane Endpointsto Minimise Suffering -- chapter 15 Euthanasia -- chapter 16 Education, Training,and Competence -- chapter 17 Animal Experimentation and Open Communication.Judge Your Practices Against This Benchmark Manual COST Action B-24 established four working groups to research and discuss issues relevant to laboratory animal science. These included the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the groups’ findings, The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research provides a consensual European view of best practices for individuals and institutions caring for and working with laboratory animals.COST Manual of Laboratory Animal Care and Use Laboratory animalsLaboratory manualsLaboratory animals636.088/5636.0885Howard BryanNevalainen TimoPerretta GemmaEuropean Cooperation in the Field of Scientific and Technical Research (Organization)FlBoTFGFlBoTFGBOOK9910411652403321The cost manual of laboratory animal care and use2116906UNINA