01372cam2-22003971i-450-99000649985040332120141209102636.0000649985FED01000649985(Aleph)000649985FED0100064998520010426g19601964km-y0itay50------baitaITa-------001yy<<L'>>opera dell'esercitotesto di Massimo Adolfo VitaleRomaIstituto poligrafico dello Stato1960-19643 v. (XXIV, 268; XXIII, 284; XXIII, 414 p.)ill.25 cmmilitare11.: Ordinamento e reclutamento : 1885-1943. - 19602.: Avvenimenti militari e impiego. Africa orientale : 1868-1934. - 19623.: avvenimenti militari e impiego. Africa orientale : 1868-1934. - 19640010006723782001<<L'>>Italia in Africa1355Vitale,Massimo Adolfo243171ITUNINARICAUNIMARCBK990006499850403321Collez. 922 (1)25109FSPBCCollez. 922 (2)25110FSPBCCollez. 922 (3)25111FSPBCSE 057.01.03-1DECSESE 057.01.03-2DECSESE 057.01.03-3DECSEFSPBCDECSEOpera dell'esercito654788UNINA01022cam0-2200349---450-99000327530020331620090618143402.088-14-14541-5000327530USA01000327530(ALEPH)000327530USA0100032753020090618d2009----|||y0itay0103----baitaIT||||||||001yySistema penale e criminalità organizzatale figure delittuose associativeSalvatore Aleo3. edMilanoGiuffrè2009XV, 319 p.24 cmCriminalità organizzata345.4502ALEO,Salvatore231435ITSALBCISBD990003275300203316XXVI.1.C 57763840 G.XXVI.1.C00226007BKGIUCHIARA9020090618USA011432CHIARA9020090618USA011434Sistema penale e criminalità organizzata629952UNISA05570nam 22007815 450 991040969880332120250609110821.03-030-40204-510.1007/978-3-030-40204-4(CKB)4100000011040240(DE-He213)978-3-030-40204-4(MiAaPQ)EBC6177148(PPN)243764170(MiAaPQ)EBC6177224(EXLCZ)99410000001104024020200415d2020 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierHSF1 and Molecular Chaperones in Biology and Cancer /edited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval1st ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (VIII, 182 p. 31 illus., 26 illus. in color.)Advances in Experimental Medicine and Biology,0065-2598 ;12433-030-40203-7 Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks – redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Advances in Experimental Medicine and Biology,0065-2598 ;1243Human geneticsCancerResearchMolecular biologyProteomicsProteinsHuman Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Cancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XProteomicshttps://scigraph.springernature.com/ontologies/product-market-codes/L1403XProtein Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/L14040Protein Structurehttps://scigraph.springernature.com/ontologies/product-market-codes/L14050ProteïnesthubOncologiathubLlibres electrònicsthubHuman genetics.CancerResearch.Molecular biology.Proteomics.Proteins.Human Genetics.Cancer Research.Molecular Medicine.Proteomics.Protein Science.Protein Structure.Proteïnes.Oncologia572.633Mendillo Marc Laurenceedthttp://id.loc.gov/vocabulary/relators/edtPincus Davidedthttp://id.loc.gov/vocabulary/relators/edtScherz-Shouval Ruthedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910409698803321HSF1 and Molecular Chaperones in Biology and Cancer2510077UNINA